Dec 1, 1975

Survival of rats subjected to acute anemia at different levels of erythrocyte 2,3-diphosphoglycerate

Scandinavian Journal of Clinical and Laboratory Investigation
G Arturson, M Westman


An experimental procedure was worked out in which rats were subjected to an exchange of erythrocytes, followed by acute anemia by means of hemodilution. One group of rats received erythrocytes with a high concentration of 2,3-diphosphoglycerate (DPG), and the other group was given erythrocytes with a low DPG concentration. The survival rate was equal in the two groups. Irrespective of DPG concentration, the rats whose hemoglobin concentration reached the lowest level died. The rats that died were also more acidotic than the others. The results indicate that the hemoglobin concentration and the pH value were more important determinants for survival than the DPG concentrations.

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Mentioned in this Paper

Blood Preservation
Diphosphoglyceric Acids
Acute Anaemia
Specimen Type - Erythrocytes
Red Blood Cell Count Measurement
Blood Transfusion
Dipstick Assessment of Hemoglobin Concentration

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