PMID: 11321386Apr 26, 2001Paper

Survival of rotavirus antibody activity derived from bovine colostrum after passage through the human gastrointestinal tract

Journal of Pediatric Gastroenterology and Nutrition
J PacynaG P Davidson

Abstract

Rotavirus is a major cause of infectious diarrhea in infants and young children. Several studies have shown that hyperimmune bovine colostrum, derived from cows immunized with rotavirus, can prevent rotavirus diarrhea when given passively. The objective of this study was to determine whether colostral antibody activity survived transit through the gut by measuring the level of rotavirus antibody activity in the feces. Hyperimmune colostrum containing different levels of rotavirus antibody was administered to 105 children attending nine Adelaide childcare centres. Subjects were asked to drink 100 ml of whole milk supplemented with colostrum 3 times a day, for a period of 6 days. Stool samples were collected from the subjects before, during, and after consumption of the study product. Rotavirus activity was determined using a novel virus reduction enzyme-linked immunosorbent assay (ELISA) and a virus neutralization assay. Rotavirus antibody activity was detected in 521 (86%) of 602 fecal specimens obtained during the study using the virus reduction ELISA. The antibody activity was detected as early as 8 hours after ingestion of hyperimmune colostrum and up to 72 hours after consumption had ceased. There was a strong relation (r =...Continue Reading

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Citations

Jan 25, 2003·Diagnostic Microbiology and Infectious Disease·Regina Célia de Souza Campos FernandesEnrique Medina-Acosta
Mar 10, 2011·Virology Journal·Karen KnippingBelinda Van't Land
Jun 5, 2015·Journal of the Science of Food and Agriculture·Julia Dugnol, Francisco A Riera
Jan 21, 2015·Critical Reviews in Biotechnology·Russell G A Jones, Angela Martino
Apr 26, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Rosaria CesaroneGiulia Vinciguerra
Jul 27, 2010·Scandinavian Journal of Gastroenterology·Cuong D TranRoss N Butler
Jul 11, 2018·Frontiers in Nutrition·Laurien H UlfmanR J Joost van Neerven

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