Survival of the Fittest: Competitive Co-crystal Reactions in the Ball Mill

Chemistry : a European Journal
Franziska FischerFranziska Emmerling

Abstract

The driving forces triggering the formation of co-crystals under milling conditions were investigated by using a set of multicomponent competitive milling reactions. In these reactions, different active pharmaceutical ingredients were ground together with a further compound acting as coformer. The study was based on new co-crystals including the coformer anthranilic acid. The results of the competitive milling reactions indicate that the formation of co-crystals driven by intermolecular recognition are influenced and inhibited by kinetic aspects including the formation of intermediates and the stability of the reactants.

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Citations

Nov 15, 2017·Drug Development and Industrial Pharmacy·Naoto SuzukiToshiro Fukami
Jun 23, 2020·Chemistry : a European Journal·Marek PotrzebowskiSlawomir Kazmierski
Mar 27, 2021·International Journal of Pharmaceutics·Rahamatullah ShaikhDenise M Croker
Jun 3, 2021·Pharmaceutics·Mizraín Solares-BrionesJuan M Germán-Acacio
Oct 11, 2017·Molecular Pharmaceutics·Naga Kiran DuggiralaRaj Suryanarayanan

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