PMID: 2508023Oct 1, 1989Paper

Survival of the vestibular nerve after labyrinthectomy in the cat

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S P CassH G Goshgarian

Abstract

Temporal bone studies in cat, monkey, and man demonstrate that the cell bodies of the primary vestibular neurons located in Scarpa's ganglion persist after labyrinthectomy. However, it is not known whether the centrally directed axon process of deafferented vestibular neurons survive or degenerate after labyrinthectomy. If the central axon were to persist, then the primary vestibular neuron could influence vestibular compensation or produce symptoms of vestibular dysfunction. In the present study the temporal bones and brain stem of four cats were prepared for light microscopic examination with hematoxylin-eosin, silver, and trichrome connective tissue stains. Cell counts within Scarpa's ganglion were performed. After labyrinthectomy, many intact axons were demonstrated in the brain stem, a finding that correlated with survival of neurons in Scarpa's ganglion. This study provides anatomic evidence that primary vestibular neurons that survive labyrinthectomy may retain their central axon processes. The persistence of this neural pathway and data from behavioral studies in the cat suggest that vestibular neurons may affect vestibular compensation after labyrinthectomy. Deafferented vestibular neurons may play a role in human vest...Continue Reading

References

Nov 1, 1979·Archives of Otolaryngology·F H LinthicumA Denia
Feb 1, 1984·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M E GlasscockS G Christiansen
Aug 22, 1983·Brain Research·D W Jensen
May 1, 1981·Acta Oto-laryngologica·J YlikoskiW F House
May 1, 1981·American Journal of Otolaryngology·J Ylikoski, A Belal
Nov 1, 1981·Acta Oto-laryngologica·E Richter, H Spoendlin

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Citations

Jan 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S P Cass, H G Goshgarian
Apr 1, 1996·The Laryngoscope·S P CassJ J DiPasquale
May 16, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qianru WuLijun Pan
Aug 25, 2004·Journal of Neuroscience Methods·Seth M PollackKenna D Peusner

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