Survival of transplanted human corneal stem cells. Case report

Acta Ophthalmologica Scandinavica
Ulf SteneviStefan Ek

Abstract

To report a case history involving long-term survival of transplanted human corneal stem cells. A male patient with severe bilateral chemical burns received six corneal transplants, all of which failed. He subsequently received combined corneal transplants and stem cell transplants, which have remained clear for 3 and 4 years respectively. One of the donors was female. We studied the gender of the epithelial cells of the cheek of the patient and of the two grafts using fixation and fluorescent in situ hybridization (FISH) analyses. In the graft from the female donor, 30% of the epithelial cells were of female origin. All the epithelial cells from the cheek and the other graft were of male origin. This case demonstrates that transplanted human corneal stem cells can survive and replicate in the long-term (3 years) without systemic immunosuppression. The case also indicates that a minority (30%) of healthy transplanted epithelial cells is enough to present a clear graft with a clinically healthy ocular surface.

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Citations

Nov 30, 2006·The Ocular Surface·Mary Ann Stepp, James D Zieske
Feb 19, 2010·Ophthalmology·Ammar MiriHarminder S Dua
Jul 21, 2005·Acta Ophthalmologica Scandinavica·Maria EgarthUlf Stenevi
Sep 29, 2005·Acta Ophthalmologica Scandinavica·Maria EgarthUlf Stenevi
Mar 15, 2005·Biology of the Cell·Ahdeah Pajoohesh-Ganji, Mary Ann Stepp
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Charles Hanson, Gunilla Caisander
Dec 4, 2003·Acta Ophthalmologica Scandinavica·Einar StefánssonAnders Heijl
Sep 27, 2003·Acta Ophthalmologica Scandinavica·Anders BehndigTimo Tervo
Nov 7, 2006·Acta Ophthalmologica Scandinavica·David HallbergUlf Stenevi
May 18, 2005·Biochemical and Biophysical Research Communications·Francesco LescaiClaudio Franceschi
Apr 29, 2015·Progress in Retinal and Eye Research·Nick Di Girolamo

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