Survival outcome and prognostic factors of neoadjuvant treatment followed by resection for borderline resectable pancreatic cancer

Annals of Surgical Treatment and Research
Hyeong Seok KimSun-Whe Kim

Abstract

Neoadjuvant treatment may provide improved survival outcomes for patients with borderline resectable pancreatic cancer (BRPC). The purpose of this study is to evaluate the clinical outcomes of neoadjuvant treatment and to identify prognostic factors. Forty patients who met the National Comprehensive Cancer Network definition of BRPC and received neoadjuvant treatment followed by surgery between 2007 and 2015 were evaluated. Prospectively collected clinicopathological outcomes were analyzed retrospectively. The mean age was 61.7 years and the male-to-female ratio was 1.8:1. Twenty-six, 3, and 11 patients received gemcitabine-based chemotherapy, 5-fluorouracil, and FOLFIRINOX, respectively. The 2-year survival rate (2YSR) was 36.6% and the median overall survival (OS) was 20 months. Of the 40 patients, 34 patients underwent resection and the 2YSR was 41.2% while the 2YSR of patients who did not undergo resection was 16.7% (P = 0.011). The 2YSR was significantly higher in patients who had partial response compared to stable disease (60.6% vs. 24.3%, P = 0.038), in patients who did than did not show a CA 19-9 response after neoadjuvant treatment (40.5% vs. 0%, P = 0.039) and in patients who did than did not receive radiotherapy (50...Continue Reading

References

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Citations

Apr 11, 2020·Annals of Surgical Treatment and Research·Atilgan Tolga AkcamAhmet Rencuzogullari
Dec 28, 2018·Annals of Hepato-biliary-pancreatic Surgery·Sung Hwan ChoYun Hak Kim
Sep 23, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ammar A JavedJin He
Jul 4, 2020·Revista de gastroenterología de México·G E Sánchez MoralesL C Chan Núñez
Mar 9, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Jonathan GarnierOlivier Turrini
Jul 24, 2021·Indian Journal of Surgical Oncology·Kailash Chand Kurdia, Vinay K Kapoor

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Methods Mentioned

BETA
surgical resection
SMA
dissection
pancreatectomy
biopsy

Software Mentioned

SPSS Statistics

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