Survival outcomes in node-negative breast cancer patients evaluated with complete axillary node dissection versus sentinel lymph node biopsy

Annals of Surgical Oncology
Charles E CoxNils Diaz

Abstract

Sentinel lymph node (SLN) biopsy combined with microstaging-associated immunohistochemical staining for cytokeratin more accurately assigns patients to their corresponding diagnostic stage. The purpose of this study was to compare the survival outcomes of node-negative patients who received an SLN biopsy with historical control data of node-negative patients who received routine complete axillary lymph node dissection (CALND) in the pre-SLN biopsy era. Under institutional review board approval, 2458 node-negative invasive breast cancer patients between the ages of 25 and 94 years (mean, 60 years) were treated at our institution from January 1986 to May 2004. Of these 2458 patients, 604 (25%) were evaluated with CALND, whereas 1854 (75%) were evaluated with SLN biopsy. All were treated according to the current stage-specific guidelines. Kaplan-Meier graphs of overall survival and disease-free survival were constructed for each group of patients, and the two groups were compared by using the log-rank test. Overall survival and disease-free survival for the CALND and SLN biopsy groups did not differ significantly (P = .98). The average number of lymph nodes extracted in the pre-SLN biopsy group was 18, whereas the average number o...Continue Reading

References

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Citations

Apr 2, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G CanaveseB Dozin
Apr 29, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G MartelliR Agresti
Jun 29, 2007·Annals of Surgical Oncology·James E GervasoniBlake Cady
Feb 21, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·D Oertli
Jan 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G CanaveseB Dozin
May 26, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Michele Gadd
Dec 12, 2012·Langenbeck's Archives of Surgery·Pamela MeiersMarkus Zuber
Jun 24, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G CanaveseA Catturich
Dec 3, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I LangerM Zuber
Oct 16, 2007·The Breast : Official Journal of the European Society of Mastology·Kristina StraalmanCharlotte Lanng
Oct 9, 2007·Seminars in Roentgenology·Beatriz B AmaralJessica W T Leung
Feb 26, 2013·The British Journal of Surgery·Y AnderssonL Bergkvist
Feb 19, 2009·International Journal of Surgical Pathology·Sharon Nofech-MozesMahmoud A Khalifa
Apr 28, 2011·Nature Reviews. Clinical Oncology·Elizabeth ComenJoan Massagué
Oct 20, 2007·Expert Review of Anticancer Therapy·Elizabeth A Mittendorf, Kelly K Hunt
Jun 6, 2007·JAAPA : Official Journal of the American Academy of Physician Assistants·Margie Glissmeyer
Apr 6, 2013·The International Journal of Biological Markers·Rosella SilvestriniMaria Grazia Daidone

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