Survival outcomes of ovarian cancer patients treated with secondary cytoreductive surgery for isolated lymph node recurrence: A systematic review of the literature

International Journal of Surgery
Vasilios PergialiotisAlexandros Rodolakis

Abstract

Isolated lymph node recurrence (ILNR) is present in 12-37% of recurrences in ovarian cancer patients. Although several studies have investigated the impact of secondary cytoreduction in these cases, consensus still lacks concerning their optimal management. The purpose of the present review is to investigate whether secondary cytoreduction benefits patients with ILNR in terms of overall survival (OS) and post-relapse survival (PRS). The present systematic review was designed using the PRISMA and AMSTAR guidelines and has been registered with PROSPERO (CRD42019122854). We searched Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases from inception until February 2019. Overall, eight studies where included that recruited a total number of 479 women. Current evidence suggests that ILNR in EOC patients should be clearly distinguished from recurrences in other sites (including peritoneal and parenchymal) as their course seems to be less aggressive. Furthermore, the implementation of secondary cytoreduction as an adjunct to standard chemotherapy should be taken into consideration in this specific group of patients as the PRS may easily reach and even extend b...Continue Reading

References

Mar 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·E Burghardt, R Winter
Sep 6, 2006·Gynecologic Oncology·Pierre BlanchardAimery de Gramont
Apr 12, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P Benedetti PaniciS Basile
Oct 22, 2008·Gynecologic Oncology·Robert E BristowDennis S Chi
Oct 4, 2013·World Journal of Surgical Oncology·Chien-Wen ChenChi-An Chen
Jan 1, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A FerreroN Biglia
Dec 15, 2015·Current Medical Research and Opinion·Xuyuan LiHaoquan Cai
May 11, 2018·Clinical Oncology : a Journal of the Royal College of Radiologists·M BommertA du Bois
Sep 2, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Valerio GallottaGabriella Ferrandina
Sep 9, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Giorgio BoganiFrancesco Raspagliesi
Oct 9, 2018·Critical Reviews in Oncology/hematology·Nicoletta StaropoliPierosandro Tagliaferri
Mar 8, 2019·The Journal of Obstetrics and Gynaecology Research·Naoko KomuraTadashi Kimura

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Citations

Feb 23, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V GallottaG Ferrandina

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