Abstract
This study investigates a series of factors, all recordable by the time of presentation of distant metastases from primary breast cancer and relates these to survival after the initiation of endocrine therapies. One hundred and ninety-one patients have received endocrine therapy as initial treatment for distant metastases. In all patients both the histological grade and oestrogen receptor (ER) status of primary tumour tissue; the lymph node stage and menopausal status at mastectomy and the disease-free interval and sites of initial metastases are available for analysis. Four of these factors have been found to contribute independently towards prolonged survival after the initiation of treatment: tumour grade, ER status, disease-free interval and sites of metastases. Employing a multivariate analysis incorporating these four factors, three groups of patients have been identified with survivals of 67, 37 and 0 per cent at 18 months on therapy. These three groups of patients contain 37, 41 and 22 per cent of the patient population respectively.
References
Oct 1, 1979·The British Journal of Surgery·H M BishopP J Doyle
Mar 1, 1977·Cancer·J L HaywardR D Rubens
Mar 17, 1984·Lancet·A HowellR A Sellwood
Sep 1, 1984·European Journal of Cancer & Clinical Oncology·M A CornbleetJ F Smyth
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·A H PatersonJ Hanson
Sep 1, 1981·British Journal of Cancer·F C CampbellJ L Haybittle
Dec 15, 1980·Cancer·R W BlameyK Griffiths
Citations
Jan 1, 1994·Breast Cancer Research and Treatment·J F RobertsonR W Blamey
Dec 1, 1989·Breast Cancer Research and Treatment·T HatschekB Nordenskjöld
Jan 1, 1992·Breast Cancer Research and Treatment·J F RobertsonR W Blamey
Nov 12, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mu-Tai LiuHao-Han Yang
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·R I NicholsonR W Blamey
Apr 20, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F EfficaceUNKNOWN EORTC-BCG-IDBBC-NDDG
Aug 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A KramerR Paridaens
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M RobainP Pouillart
Mar 23, 2001·Breast Cancer Research and Treatment·K L CheungJ F Robertson
Dec 25, 2003·Breast Cancer Research and Treatment·Brigitte RackKlaus Friese
Apr 4, 2014·PloS One·Hui MiaoHelena M Verkooijen
Jul 1, 1997·Cancer Treatment Reviews·J Robertson
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I Mittra
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I Mittra, K D MacRae
Jan 1, 1989·Acta Oncologica·S LundgrenE Utaaker
Aug 14, 2003·British Journal of Cancer·J J JamesJ F R Robertson
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I JatoiC K Osborne