Abstract
We aimed to describe and compare survival in teenagers and young adults (TYAs) with cancer to that of younger children and older adults, to identify sub-populations at greater or lesser risk of death. We compared survival in cancer patients diagnosed in the United Kingdom aged 13-24 years (TYAs) to those aged 0-12 (children) and 25-49 years (adults) using the National Cancer Data Repository. All cases had a first cancer diagnosis between 1st January 2001 and 31st December 2005 with censor date 31st December 2010 or death if earlier. We found six distinct statistically significant survival patterns. In pattern 1, the younger the age-group the better the 1- and 5-year survival (acute lymphoid leukaemia, carcinoma of ovary and melanoma). In pattern 2, TYAs had a worse 5-year survival than both children and young adults (bone and soft tissues sarcomas). In pattern 3, TYAs had a worse 1-year survival but no difference at 5-years (carcinoma of cervix and female breast). In pattern 4, TYAs had better 1-year survival than adults, but no difference at 5 years (carcinoma of liver and intrahepatic bile ducts, germ cell tumours of extra-gonadal sites). In pattern 5, the younger the age-group the better the 5-year survival, but the differen...Continue Reading
References
Jan 1, 1986·Journal of the American Geriatrics Society·J S GoodwinC Hunt
May 15, 1993·Annals of Internal Medicine·D J St JohnE S Hughes
Dec 4, 1998·BMJ : British Medical Journal·J M Bland, D G Altman
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicolas BoisselAndré Baruchel
Dec 26, 2003·Statistics in Medicine·Paul W DickmanTimo Hakulinen
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE Steliarova-Foucher
Oct 26, 2006·The American Journal of Surgical Pathology·Elvio G SilvaMichael Deavers
Mar 21, 2008·Nature Reviews. Cancer·Archie BleyerUNKNOWN Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adul
Jan 28, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Milena SantUNKNOWN EUROCARE Working Group
Feb 24, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gemma GattaUNKNOWN EUROCARE Working Group
May 21, 2011·Journal of the National Cancer Institute·Sabine TejparArnaud D Roth
Jun 11, 2011·BMJ : British Medical Journal·Laura M WoodsBernard Rachet
Jul 28, 2011·Pediatric Blood & Cancer·Andrea FerrariSheri L Spunt
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jeremy WhelanSandra J Strauss
Nov 2, 2011·Journal of the American Academy of Dermatology·Hannah K WeirDonatus U Ekwueme
Apr 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander M MenziesGeorgina V Long
Oct 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Archie BleyerNita L Seibel
Oct 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerUNKNOWN RARECARE Working Group
Nov 28, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·B D NicholsonR G Feltbower
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ayal A AizerPaul L Nguyen
Nov 25, 2014·Journal of the National Cancer Institute. Monographs·Denise Riedel LewisMargaret R Stedman
Jul 30, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C O'HaraM G McCabe
Citations
Jan 13, 2017·Journal of Adolescent and Young Adult Oncology·Simon A PiniDan P Stark
Feb 7, 2017·Journal of Adolescent and Young Adult Oncology·Gemma PughAbigail Fisher
Apr 11, 2018·Journal of Adolescent and Young Adult Oncology·Judith FortmannGemma Pugh
Apr 19, 2018·Pediatric Blood & Cancer·Archie BleyerStuart Siegel
Jul 24, 2018·Journal of Adolescent and Young Adult Oncology·Lesley SmithDan Stark
May 16, 2020·Journal of Adolescent and Young Adult Oncology·Thomas RazeEmmanuel Desandes
Jun 24, 2020·Cancers·Roberta BurnelliMaurizio Mascarin
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Joseph M UngerArchie Bleyer
Dec 26, 2018·Clinical Rehabilitation·Oana C LindnerAlison Wearden
Feb 8, 2020·British Journal of Haematology·Ardine M J ReedijkHenrike E Karim-Kos
Mar 12, 2017·Annals of Global Health·Mahshid GhonchehHamid Salehiniya
Mar 5, 2017·BMC Cancer·Lesley FairleyRichard G Feltbower
Nov 14, 2019·British Journal of Cancer·Klaus RostgaardLisa L Hjalgrim
Jul 25, 2018·Pediatric Blood & Cancer·V M WhiteA Anazodo
Jun 5, 2020·European Journal of Cancer Care·Oana C LindnerDan Stark
Mar 29, 2019·Cancer Nursing·Judith FortmannGemma Pugh
Mar 12, 2021·Journal of Adolescent and Young Adult Oncology·Sarah LeaRachel M Taylor