Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography

EBioMedicine
Yan WuZhaoming Ye

Abstract

The poor 5-year survival rate in high-grade osteosarcoma (HOS) has not been increased significantly over the past 30 years. This work aimed to develop a radiomics nomogram for survival prediction at the time of diagnosis in HOS. In this retrospective study, an initial cohort of 102 HOS patients, diagnosed from January 2008 to March 2011, was used as the training cohort. Radiomics features were extracted from the pretreatment diagnostic computed tomography images. A radiomics signature was constructed with the lasso algorithm; then, a radiomics score was calculated to reflect survival probability by using the radiomics signature for each patient. A radiomics nomogram was developed by incorporating the radiomics score and clinical factors. A clinical model was constructed by using clinical factors only. The models were validated in an independent cohort comprising 48 patients diagnosed from April 2011 to April 2012. The performance of the nomogram was assessed with respect to its calibration, discrimination, and clinical usefulness. Kaplan-Meier survival analysis was performed. The radiomics nomogram showed better calibration and classification capacity than the clinical model with AUC 0.86 vs. 0.79 for the training cohort, and 0...Continue Reading

Citations

Jun 20, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Zhen-Yu ShuQin-Yang Jin
Feb 6, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F C F DionísioM H Nogueira-Barbosa
Jan 16, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Peng LinZhao-Ming Ye
Aug 28, 2020·Frontiers in Public Health·Deng PanTao Xu
Jun 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniMargarita Kirienko
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Zhanbo OuyangQiong Lu
Mar 7, 2021·The Spine Journal : Official Journal of the North American Spine Society·Andrew J Vickers, Ford Holland
Jun 20, 2020·European Journal of Radiology·Guangjie YangZhenguang Wang
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Methods Mentioned

BETA
biopsy
amputation
Feature Extraction

Software Mentioned

ITK
Picture Archiving and Communication System PACS
R
SNAP
MATLAB
LASSO
generalhoslem
MedCalc
PASS

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