Survival Rates after Thermal Ablation versus Stereotactic Radiation Therapy for Stage 1 Non-Small Cell Lung Cancer: A National Cancer Database Study

Radiology
Johannes UhligHyun S Kim

Abstract

Purpose To compare survival rates of thermal ablation and stereotactic radiation therapy (SRT) for stage 1 non-small cell lung cancer (NSCLC). Materials and Methods In this retrospective study, patients with stage 1 NSCLC treated by thermal ablation (TA) or SRT were identified in the 2004-2013 National Cancer Database. Patients who underwent TA and SRT were one-to-one propensity matched to undergo thermal ablation. Outcomes were overall survival and unplanned hospital readmission within 30 days after treatment. Results This study included 28 834 patients (TA, 1102 patients; SRT, 27 732 patients). Patients treated with TA had more comorbidities (Charlson comorbidity index of 1 vs ≥2, 32.8% [362 of 1102] vs 19.7% [217 of 1102], respectively) compared with SRT (Charlson comorbidity index of 1 vs ≥2, 26.9% [7448 of 27 732] vs 15.3% [4251 of 27 732], respectively; P , .001) and smaller tumor size (mean tumor size, TA vs SRT: 19 mm vs 22 mm, respectively; P , .001). In the propensity score-matched cohort with balanced distribution of potential confounders, there was no significant difference in overall survival between TA and SRT at a mean follow-up of 52.4 months (survival difference, P = .69). Overall survival rates were comparable...Continue Reading

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Citations

May 8, 2019·Cardiovascular and Interventional Radiology·Pernelle LavaudLambros Tselikas
Jul 25, 2020·The British Journal of Radiology·Thomas Helmberger
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Yang NiXin Ye
Dec 14, 2018·Journal for Immunotherapy of Cancer·Lucas C AdamHyun S Kim
Sep 21, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jean PalussièreFrançois Chomy
Feb 26, 2020·Cardiovascular and Interventional Radiology·Massimo VenturiniGianpaolo Carrafiello
Jul 25, 2019·Medicina·Roxana AmirahmadiJanaki Deepak
Oct 9, 2019·Journal of Thoracic Imaging·Darragh HalpennyMichelle S Ginsberg
Apr 30, 2021·Insights Into Imaging·Alfredo Páez-CarpioIvan Vollmer
Apr 4, 2021·Journal of Vascular and Interventional Radiology : JVIR·Johannes UhligHyun S Kim

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