PMID: 9422559Jan 9, 1998Paper

Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma

International Journal of Radiation Oncology, Biology, Physics
E L ChangC N Coleman

Abstract

To report the survival results from a previous Phase I study of etanidazole (ETA) and radiotherapy in patients with glioblastoma multiforme (GBM n = 50) or anaplastic astrocytoma (AA n = 19) and examine survival according to age, Karnofsky performance status (KPS), and implant status. In a previous Phase I study, 70 previously untreated patients (median age 49) with malignant gliomas were accrued. One patient was excluded from analysis because pathology was unverifiable. All had KPS > or = 70. Prior to initiation of treatment, patients were stratified according to whether they were candidates for interstitial implantation. The implant patients (IMP n = 14) received accelerated fractionation radiotherapy (XRT) 2 Gy BID (6 hours apart) to 40 Gy in 2 weeks with ETA 2 gm/m2 x 6 doses, a 2 week break, and then interstitial implant for an additional 50 Gy (4-7 days) with a continuous infusion of ETA over 90-96 hours. There were 55 patients treated on two sequentially conducted non-implant arms. These patients started with accelerated fractionation XRT 2 Gy BID (6 hours apart) to 40 Gy in 2 weeks with ETA 2 gm/m2 x 4-5 doses/week. Non-IMP1 arm (n = 41) received a 2-week break before standard fractionated boost XRT of 2 Gy/day for 2 we...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C O ScharfenK R Lamborn
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S J HurwitzR A Kramer
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·C N ColemanT L Phillips
Dec 19, 1990·Journal of the National Cancer Institute·J S LoefflerN E Riese
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·C N ColemanR A Kramer
Jan 1, 1987·Journal of Neurosurgery·S A Leibel, G E Sheline
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·N E RieseC N Coleman

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