Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling

Journal of Cellular Physiology
Filippo AcconciaMaria Marino

Abstract

The capability of 17beta-estradiol (E2) to induce the non-genomic activities of its receptors (ER alpha and ER beta) and to evoke different signaling pathways committed to the regulation of cell proliferation has been analyzed in different cell cancer lines containing transfected (HeLa) or endogenous (HepG2, DLD1) ER alpha or ER beta. In these cell lines, E2 induced different effects on cell growth/apoptosis in dependence of ER isoforms present. The E2-ER alpha complex rapidly activated multiple signal transduction pathways (i.e., ERK/MAPK, PI3K/AKT) committed to both cell cycle progression and apoptotic cascade prevention. On the other hand, the E2-ER beta complex induced the rapid and persistent phosphorylation of p38/MAPK which, in turn, was involved in caspase-3 activation and cleavage of poly(ADP-ribose)polymerase, driving cells into the apoptotic cycle. In addition, the E2-ER beta complex did not activate any of the E2-ER alpha-activated signal molecules involved in cell growth. Taken together, these results demonstrate the ability of ER beta isoform to activate specific signal transduction pathways starting from plasma membrane that may justify the effect of E2 in inducing cell proliferation or apoptosis in cancer cells....Continue Reading

References

Mar 1, 1983·European Journal of Cancer & Clinical Oncology·R L SutherlandM D Green
May 16, 1998·Biochemical and Biophysical Research Communications·M MarinoA Trentalance
May 6, 1999·The EMBO Journal·G CastoriaF Auricchio
Jul 30, 1999·Biochemical and Biophysical Research Communications·G FiorelliM L Brandi
Sep 8, 2000·Molecular Endocrinology·M RazandiE R Levin
Sep 16, 2000·The Journal of Biological Chemistry·M RazandiE R Levin
Aug 14, 2001·Molecular and Cellular Endocrinology·M MarinoC L Smith
Nov 22, 2001·Journal of the National Cancer Institute·R X SongR J Santen
Dec 4, 2001·Biology of the Cell·C Ambrosino, A R Nebreda
Jul 26, 2002·Molecular and Cellular Biology·Heehyoung Lee, Wenlong Bai
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·D B DubalP M Wise
Dec 13, 2002·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·A Di LeoM Linsalata
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Hye-Jung KangAree Moon
Jan 3, 2003·Apoptosis : an International Journal on Programmed Cell Death·R X-D Song, R J Santen
May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A KonstantinopoulosA G Papavassiliou
Jun 17, 2003·Molecular Biology of the Cell·Maria MarinoAnna Trentalance
Jun 28, 2003·FEBS Letters·Zhang WeihuaJan-Ake Gustafsson
Nov 18, 2003·Molecular Biology of the Cell·Almudena PorrasAngel R Nebreda
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anders StrömJan-Ake Gustafsson
Mar 3, 2004·Molecular Interventions·Jason Matthews, Jan-Ake Gustafsson
Mar 17, 2004·The Journal of Biological Chemistry·Huifang M ZhangJian-Ying Wang
Mar 23, 2004·Biochemical and Biophysical Research Communications·Filippo AcconciaMaria Marino

❮ Previous
Next ❯

Citations

Oct 14, 2008·Genes & Nutrition·Paola Galluzzo, Maria Marino
Feb 24, 2007·Applied Microbiology and Biotechnology·Margarita M IvanovaCarolyn M Klinge
Sep 28, 2010·Journal of Gastrointestinal Cancer·Hosam Ghazy ElbannaMaha Abo Hashim
Jul 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Jing FangDe-Sen Wan
Oct 22, 2004·Molecular Biology of the Cell·Filippo AcconciaMaria Marino
Jul 23, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ana M Covaleda SotocaAlbertinka J Murk
Jan 31, 2012·Biology of Sex Differences·Ilaria CampesiFlavia Franconi
Jun 1, 2009·Journal of Toxicologic Pathology·Zaher A RadiDale L Morris
Mar 4, 2014·PloS One·Piergiorgio La RosaMaria Marino
Jun 5, 2013·Journal of Molecular Endocrinology·Chuan-Chou TuChih-Yang Huang
Oct 27, 2010·The Journal of Endocrinology·Rhone A MendozaGudmundur Thordarson
Oct 22, 2008·World Journal of Gastroenterology : WJG·Mamta KalraRashmi Kaul
Aug 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Veronica StabilePaolo Chieffi
Oct 16, 2009·European Journal of Endocrinology·Guia VannucchiLaura Fugazzola
Oct 10, 2014·Cell Death & Disease·M FiocchettiM Marino
Mar 8, 2012·Immunopharmacology and Immunotoxicology·Ayako YamaguchiYoshinari Takasaki
Feb 24, 2015·Frontiers in Oncology·Francesco CaiazzaKieran Sheahan
May 20, 2016·Endocrine-related Cancer·Habibur P RahmanPaul A Foster
Oct 29, 2008·The Journal of Steroid Biochemistry and Molecular Biology·A M SotocaA J Murk
Mar 25, 2016·Scientific Reports·Pierangela TottaFilippo Acconcia
Aug 9, 2005·Cancer Letters·Filippo Acconcia, Rakesh Kumar
Sep 19, 2006·Yi chuan xue bao = Acta genetica Sinica·Zong-Bin LiJian Lu
Nov 22, 2017·Antioxidants·Raffaella ComitatoFabio Virgili
Dec 9, 2017·Journal of Cellular Physiology·Marco FiocchettiMaria Marino
Oct 20, 2015·Journal of Cellular Physiology·Pierangela TottaFilippo Acconcia
Mar 19, 2014·Acta Physiologica Hungarica·A HassounaMohamed Haidara

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis