Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis

Cell Death & Disease
Miriam EjarqueSonia Fernández-Veledo

Abstract

Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin. Within AT, survivin was primarily detected in human adipocyte-derived stem cells (hASCs), the adipocyte precursors that determine AT expansion. Remarkably, survivin expression was significantly higher in hASCs isolated from obese patients that from lean controls and was increased by proinflammatory M1 macrophage soluble factors including IL-1β. Analysis of survivin expression in hASCs revealed a complex regulation including epigenetic modifications and protein stability. Surprisingly, obese hASCs showed survivin promoter hypermethylation that correlated with a significant decreas...Continue Reading

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Citations

May 23, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Andrew RedfernErik W Thompson
Feb 9, 2020·Journal of Clinical Pathology·Hisham F Bahmad, Robert J Poppiti
Sep 29, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Miriam EjarqueSonia Fernández-Veledo
Jul 22, 2020·Stem Cell Reviews and Reports·Neerada Meenakshi WarrierPraveen Kumar
Jun 18, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Andrea G IzquierdoAna B Crujeiras
Aug 28, 2020·Frontiers in Oncology·Vittoria D'EspositoPietro Formisano
Mar 13, 2021·Cellular Oncology (Dordrecht)·E BenaigesS Fernández-Veledo
Apr 5, 2021·Annals of Surgical Oncology·Nicole T GordonNina A Bickell

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Methods Mentioned

BETA
PCR
SGBS
ELISA
flow cytometry

Software Mentioned

Geospiza FinchTV
Quantity One
Statistical Package for the Social Sciences software
BD
FACSDiva

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