Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms

Journal of Molecular Histology
Mehmet KanterBetül Kanter

Abstract

The most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Immunohistochemical analysis revealed that survivin and cyclin D1 expressions were located primarily in the nucleus of ovarian tumor cells and relatively weaker cytoplasmic staining. Survivin expression was significantly higher in malignant tumors (88.1 %) than those found in borderline (18.2 %) and benign tumors (8.8 %) (p < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (100 %) compared to borderline (36.4 %) and benign tumors (5.9 %) (p < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from ben...Continue Reading

References

Feb 1, 1997·Gynecologic Oncology·S D WorsleyB R Davies
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Nov 7, 2000·Cancer·B A GoffC H Melancon
Oct 5, 2002·Cellular and Molecular Life Sciences : CMLS·N ZaffaroniM G Daidone
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cynthia CohenRobert Santoianni
May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Barbara TringlerKenneth R Shroyer
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hector BiliranJoshua D Liao
Dec 14, 2005·International Review of Cytology·Sally P Wheatley, Iain A McNeish
Aug 29, 2006·Current Opinion in Cell Biology·Dario C Altieri
Jun 10, 2008·Cancer Science·Hirofumi YamamotoMorito Monden
Feb 28, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Chih-Kung LinJong-Shiaw Jin
Mar 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Min ZhangArnab Chakravarti
Aug 21, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xueya QianLinxia Li
Dec 15, 2010·International Journal of Molecular Sciences·Wei LiLing-Yun Zhai
Nov 15, 2011·Journal of Ovarian Research·Anna Felisiak-GolabekUNKNOWN Polish Ovarian Cancer Study Group (POCSG)
Jan 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lifeng ChenFeiyun Zheng
Aug 27, 2013·Archives of Gynecology and Obstetrics·Umran Kucukgoz GulecAytekin Altintas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved