Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells

Leukemia Research
Xiaofang WangCheng Yao

Abstract

In this study we investigated the influence of the mesenchymal stem cells on the survival of U266 and H929 myeloma cell lines. We found that both soluble factors and direct cell contact inhibited daunorubicin-induced apoptosis of U266 and H929 cells. The mRNA and protein levels of survivin were upregulated in U266 and H929 cells cocultured with mesenchymal stem cells, whereas not increased in that separated by TW insert. Antisense oligonucleotides targeting survivin downregulated the expression of survivin and increased the apoptosis of U266 and H929 cells. The results indicated that MSCs had anti-apoptotic effect on U266 and H929 cells that was mediated by survivin.

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Citations

Aug 9, 2011·Journal of Biomedicine & Biotechnology·Rebecca S Y Wong
Nov 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaela R Reagan, Irene M Ghobrial
Nov 2, 2012·The Journal of Clinical Investigation·Andrea J Mothe, Charles H Tator
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Feb 14, 2013·World Neurosurgery·Asdrubal Falavigna, Jaderson Costa da Costa
Sep 2, 2014·Molecular Medicine Reports·Renhong He, Jianzhong Fan
Nov 9, 2018·International Journal of Molecular Sciences·Chia-Hung Yen, Hui-Hua Hsiao
Sep 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanne J de HaartTuna Mutis

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