Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis

Biochemical and Biophysical Research Communications
Shao-Chen SunQing-Yuan Sun

Abstract

Survivin is a member of inhibitors of apoptosis proteins (IAPs), and also belongs to be a member of the chromosomal passenger complex (CPC) which has multiple functions including inhibition of apoptosis and regulation of cell division and SAC activity. Plk1 (polo-like kinase 1) associates with the spindle poles and also distributes to the kinetochores and is shown to involve in spindle organization, APC/C activation and cytokinesis in many models. Our recent work has shown that Survivin is a critical regulator of chromosome segregation and spindle assembly checkpoint (SAC) in meiosis. In the present study, we found that Plk1 co-localized with Survivin at metaphase I (MI) and telophase I (TI) stage after GVBD. Plk1 dispersed into the oocyte cytoplasm or accumulated near the chromosomes after the depletion of Survivin by morpholino (MO) injection. Our results showed that the localization of Plk1 to kinetochores required the involvement of Survivin.

References

Aug 29, 2006·Current Opinion in Cell Biology·Dario C Altieri
Sep 8, 2009·Trends in Cell Biology·Patrick Steigemann, Daniel W Gerlich
Dec 3, 2009·The Journal of Cell Biology·Zhenjie XuKumiko Samejima
Jan 27, 2011·Molecular Human Reproduction·Shao-Chen SunNam-Hyung Kim
Jun 10, 2011·Cell Cycle·Guillermo de CárcerMarcos Malumbres
Nov 17, 2011·Human Reproduction Update·Shao-Chen Sun, Nam-Hyung Kim

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Citations

Jun 15, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shao-Chen Sun, Nam-Hyung Kim
Feb 18, 2016·Zygote : the Biology of Gametes and Early Embryos·Paulo R AdonaSamuel Guemra
Jan 12, 2017·Journal of Assisted Reproduction and Genetics·Zixiao ZhangShiqiang Ju
Aug 29, 2018·Environmental and Molecular Mutagenesis·Xiang WanShao-Chen Sun
Apr 9, 2020·Molecular Biology of the Cell·Tara M Little, Philip W Jordan
Nov 30, 2018·Journal of Veterinary Science·Jeonghyeon Moon, Sangho Roh
Nov 29, 2020·Molecular Cell·Priyanka SinghAndrea Musacchio

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