Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.

Intensive Care Medicine
Scott L WeissPierre Tissieres

Abstract

To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed t...Continue Reading

Associated Clinical Trials

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Citations

May 27, 2020·Intensive Care Medicine·George BriassoulisStavroula Ilia
May 10, 2020·European Journal of Pediatrics·Felipe Yu MatsushitaWerther Brunow de Carvalho
Aug 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luregn J SchlapbachKonrad Reinhart
May 28, 2020·European Journal of Pediatrics·Masashi HottaKazuko Wada
Jun 24, 2020·Intensive Care Medicine·Pierre TissieresScott L Weiss
Sep 5, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissUNKNOWN Children’s Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ
Nov 21, 2020·Acta Anaesthesiologica Scandinavica·Lars Broksø HolstLene Russell
Nov 20, 2020·Hospital Pediatrics·Mukul SehgalBalagangadhar Totapally
Jan 13, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David T SelewskiTheresa Ann Mottes
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Dec 19, 2020·Critical Care Medicine·Fiona MuttalibUNKNOWN PALISI Global Health Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)
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Feb 17, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·K Taneille JohnsonSrinivas Murthy
Oct 13, 2020·Frontiers in Oncology·Matt S ZinterJeffery J Auletta
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Dec 11, 2020·The Pediatric Infectious Disease Journal·Christian Magnus ThaulowStig Harthug
Apr 27, 2021·JAMA : the Journal of the American Medical Association·Srinivas MurthyScott Berry
Apr 19, 2021·Australasian Emergency Care·Amanda HarleyDebbie Massey
May 28, 2021·Frontiers in Pediatrics·Luregn J SchlapbachUNKNOWN RESPOND PICU study investigators and the Australian New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG)
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Jun 24, 2021·Medicine·Thomas SchmochThorsten Brenner

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Methods Mentioned

BETA
blood draw
sedation

Clinical Trials Mentioned

NCT03080038
NCT02902055

Software Mentioned

GRADEpro GDT
Cochrane
Review Manager
TAMOF
PALICC
gLobal
SurveyMonkey
RevMan
PEMVECC
SQUEEZE

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