Survivorship and mortality implications of developmental 670-nm phototherapy: dioxin co-exposure

Photomedicine and Laser Surgery
Ronnie L YeagerDiane S Henshel

Abstract

We assessed the effect of 670-nm light therapy on dioxin-induced embryonic mortality in chickens (Gallus gallus). Developmental photobiomodulation using 670-nm light-emitting diode (LED) arrays improves hatching success and increases body size in hatchling chickens. Photobiomodulation also stimulates signaling pathways resulting in improved energy metabolism, antioxidant production and cell survival. Dioxin causes embryonic mortality, including increases in the frequency of chicken embryos that pip but can't go to hatch. We hypothesized that 670-nm LED therapy would attenuate dioxin-induced embryo mortality. Fertile chicken eggs were injected with control or 2, 20, or 200 ppt 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) prior to the start of incubation. Half of the eggs in each dose group were treated once per day from embryonic days 0-20 with 670-nm LED light at a fluence of 4 J/cm(2). In ovo survival and hatching success were compared between dose groups and LED treatment. LED therapy decreased the embryonic mortality rate by 41%, resulting in increased embryonic survival and improved hatching success in eggs exposed to 200 ppt dioxin. However, at sub-lethal dioxin concentrations and in oil-treated controls, LED therapy...Continue Reading

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Jun 16, 2005·Photomedicine and Laser Surgery·Ronnie L YeagerDiane S Henshel

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Citations

May 19, 2006·Photomedicine and Laser Surgery·Kristina D DesmetHarry T Whelan
Jul 31, 2008·Photomedicine and Laser Surgery·Joseph Tafur, Paul J Mills
Dec 17, 2009·Photomedicine and Laser Surgery·Ana Paula Cavalcanti de SousaAntônio L B Pinheiro
Aug 30, 2008·Journal of Biochemical and Molecular Toxicology·Jinhwan LimDiane S Henshel
May 21, 2011·Photomedicine and Laser Surgery·Ana Paula Cavalcanti de SousaAntônio Luiz Barbosa Pinheiro

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