Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products

Dose-response : a Publication of International Hormesis Society
Essam Hassan MohamedHamada H Amer

Abstract

The aim of this study was to examine the effect of some natural compounds against multidrug-resistant bacteria. Forty-three bacterial strains were collected. Disc diffusion and minimum inhibitory concentration (MIC) tests were carried out for natural compounds including quercetin, Acacia nilotica, Syzygium aromaticum, and Holothuria atra. Scanning electron microscope analysis and bacterial DNA apoptosis assays were performed. Staphylococcus aureus strains were resistant to imipenim, ampicillin, and penicillin. Most Escherichia coli strains were resistant to amoxicillin, clavulanat, and ampicillin. Finally, tigecycline was effective with Klebsiella pneumoniae and was resistant to all antibiotics. Only S aromaticum had an antibacterial effect on K pneumoniae. Most S aureus strains were sensitive to S aromaticum, A nilotica, and quercetin. All examined natural extracts had no effect on E coli. Holothuria atra had no effect on any of the strains tested. Minimum inhibitory concentration and minimum bactericidal concentration values for examined plants against S aureus were 6.25 to 12, 1.6 to 3.2, and 9.12 to 18.24 mg/mL, respectively. Syzygium aromaticum was active against K pneumoniae with an MIC of 12.5 mg/mL. Scanning electron mi...Continue Reading

References

Nov 3, 1995·Science·R F Service
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Mar 31, 2000·Experimental Cell Research·S Nagata
Oct 26, 2000·Current Opinion in Microbiology·S Monroe, R Polk
May 23, 2002·Antimicrobial Agents and Chemotherapy·John M ClementsMichael G Hunter
Dec 28, 2004·Journal of Ethnopharmacology·Hugo J de BoerJolanta J Levenfors
Oct 11, 2005·Current Opinion in Pharmacology·Robert PennerKaren L Madsen
Nov 8, 2005·Journal of Ethnopharmacology·Pulok K Mukherjee, Atul Wahile
Oct 18, 2006·BMC Complementary and Alternative Medicine·Veeramuthu DuraipandiyanSavarimuthu Ignacimuthu
Jan 27, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Brahma N SinghH B Singh
Jul 2, 2011·BMC Complementary and Alternative Medicine·Yamin BibiMuhammad Zia
Aug 26, 2014·Jundishapur Journal of Microbiology·Neda AdibpourAbdolghani Ameri
Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian-Guo XuXin-Ming Cao
Sep 20, 2016·Journal de mycologie médicale·S Mashjoor, M Yousefzadi
Jan 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Bilal SadiqAnil Kumar Anal
Jun 18, 2017·International Journal of Molecular Sciences·Qing LiuHua-Bin Li
Oct 23, 2018·Phytotherapy Research : PTR·Faegheh FarhadiMilad Iranshahy

❮ Previous
Next ❯

Citations

Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Najwan JubairAyesha Fatima

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
DNA
cleavage assay
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.