Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele

Development and Psychopathology
Elisa M TruccoR A Zucker

Abstract

Understanding factors increasing susceptibility to social contexts and predicting psychopathology can help identify targets for prevention. Persistently high externalizing behavior in adolescence is predictive of psychopathology in adulthood. Parental monitoring predicts low externalizing behavior, yet youth likely vary in the degree to which they are affected by parents. Genetic variants of GABA receptor subunit alpha-2 (GABRA2) may increase susceptibility to parental monitoring, thus impacting externalizing trajectories. We had several objectives: (a) to determine whether GABRA2 (rs279827, rs279826, rs279858) moderates the relationship between a component of parental monitoring, parental knowledge, and externalizing trajectories; (b) to test the form of this interaction to assess whether GABRA2 variants reflect risk (diathesis-stress) or susceptibility (differential susceptibility) factors; and (c) to clarify GABRA2 associations on the development of problem behavior. This prospective study (N = 504) identified three externalizing trajectory classes (i.e., low, decreasing, and high) across adolescence. A GABRA2 × Parental Monitoring effect on class membership was observed, such that A-carriers were largely unaffected by paren...Continue Reading

References

Jan 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·H D Chilcoat, J C Anthony
Jan 15, 1999·Hematology/oncology Clinics of North America·C J FabianJ H Ward
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·B Muthén, L K Muthén
Oct 4, 2000·Child Development·H Stattin, M Kerr
Apr 28, 2001·Clinical Child and Family Psychology Review·T J Dishion, R J McMahon
Jun 5, 2001·Pediatrics·R J DiClementeM K Oh
Jul 5, 2001·The Australian and New Zealand Journal of Psychiatry·T M Achenbach
Jan 29, 2003·Development and Psychopathology·Eric LacourseRichard E Tremblay
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan CovaultHenry R Kranzler
Feb 11, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amira Pierucci-LaghaHenry R Kranzler
Jun 14, 2005·Brain Research. Molecular Brain Research·Huijun TianHoward J Edenberg
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael RutterAvshalom Caspi
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Joel T Nigg
Jul 29, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mary-Anne EnochDavid Goldman
Oct 24, 2007·Alcoholism, Clinical and Experimental Research·Lance O BauerHenry R Kranzler
Apr 22, 2008·Development and Psychopathology·Candice L OdgersAvshalom Caspi
May 15, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Colin A HodgkinsonDavid Goldman
Jun 18, 2009·JAMA : the Journal of the American Medical Association·Neil RischKathleen Ries Merikangas
Nov 4, 2009·Psychological Bulletin·Jay Belsky, Michael Pluess
Dec 10, 2009·The British Journal of Developmental Psychology·Sofie KuppensDaisy Michiels
Nov 3, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jay Belsky, Kevin M Beaver
Apr 13, 2011·Journal of Surgical Education·Igor BelyanskyRichard F Heitmiller
Jul 12, 2012·Development and Psychopathology·Daniel S ShawLauretta M Brennan
Sep 19, 2012·Psychological Methods·Keith F WidamanJay Belsky
Jan 9, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gene H BrodySteven R H Beach
Apr 10, 2013·Genes, Brain, and Behavior·S VillafuerteM Burmeister
Jul 6, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Graeme FairchildIan M Goodyer

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Citations

Aug 20, 2016·Genes, Brain, and Behavior·D N StephensT Duka
Jun 16, 2017·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Amanda N NoroñaBruce L Baker
Jul 28, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Mayumi OkudaCristiane S Duarte
Jan 14, 2020·Current Addiction Reports·Elisa M TruccoMichelle Villar
Feb 21, 2018·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Elisa M TruccoMary M Heitzeg
Aug 23, 2018·Development and Psychopathology·Jennifer E LansfordDario Bacchini
Jan 14, 2020·Child & Adolescent Social Work Journal : C & a·Barry LadisNicole M Fava
Feb 12, 2017·Prevention Science : the Official Journal of the Society for Prevention Research·Michael A RussellDavid J Vandenbergh
Nov 1, 2020·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Gabriel L SchlomerDavid J Vandenbergh
Nov 18, 2020·Journal of Nursing Measurement·Caroline HandschuhArlene Smaldone

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