Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study

Journal of Clinical Neurology
Xiang LinShu-Feng Lei

Abstract

Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system. The aim of this study was to identify more genes associated with MS. Based on the publicly available data of the single-nucleotide polymorphism-based genome-wide association study (GWAS) from the database of Genotypes and Phenotypes, we conducted a powerful gene-based GWAS in an initial sample with 931 family trios, and a replication study sample with 978 cases and 883 controls. For interesting genes, gene expression in MS-related cells between MS cases and controls was examined by using publicly available datasets. A total of 58 genes was identified, including 20 "novel" genes significantly associated with MS (p<1.40×10⁻⁴). In the replication study, 44 of the 58 identified genes had been genotyped and 35 replicated the association. In the gene-expression study, 21 of the 58 identified genes exhibited differential expressions in MS-related cells. Thus, 15 novel genes were supported by replicated association and/or differential expression. In particular, four of the novel genes, those encoding myelin oligodendrocyte glycoprotein (MOG), coiled-coil alpha-helical rod protein 1 (CCHCR1), human leukocyte antigen complex group 22 (HCG22...Continue Reading

References

Aug 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·P FileticiP Ballario
Jul 24, 2004·American Journal of Human Genetics·Benjamin M Neale, Pak C Sham
Mar 21, 2007·Journal of the Neurological Sciences·Thomas Berger, Markus Reindl
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Nov 18, 2008·Human Molecular Genetics·Sergio E BaranziniJorge R Oksenberg
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jun 10, 2009·Neurology·M J D'NettoG C Ebers
Jun 16, 2009·Nature Genetics·UNKNOWN Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)
Nov 26, 2009·Autoimmunity Reviews·Ron Milo, Esther Kahana
Dec 19, 2009·BMC Proceedings·Alfonso BuilJose Manuel Soria
Jan 21, 2010·European Journal of Human Genetics : EJHG·Antonio AlcinaFuencisla Matesanz
Feb 18, 2010·American Journal of Human Genetics·Eveliina JakkulaLeena Peltonen
Jul 6, 2010·American Journal of Human Genetics·Jimmy Z LiuStuart Macgregor
Jan 11, 2011·Brain : a Journal of Neurology·Viviana AnnibaliMarco Salvetti
Mar 15, 2011·American Journal of Human Genetics·Miao-Xin LiPak C Sham
Jun 10, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khadir RaddassiDavid A Hafler
Aug 13, 2011·Nature·UNKNOWN International Multiple Sclerosis Genetics ConsortiumAlastair Compston
Dec 23, 2011·Clinical Reviews in Allergy & Immunology·Jin NakaharaNorihiro Suzuki
Dec 23, 2011·Annals of Neurology·Nikolaos A PatsopoulosPaul I W de Bakker
Dec 23, 2011·Human Mutation·Mun-Gwan HongJonathan A Prince
Jan 19, 2012·Multiple Sclerosis : Clinical and Laboratory Research·A LutterottiR Martin
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Jan 26, 2013·Neurology·Daniel SelchenMark Freedman

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