PMID: 11899300Mar 20, 2002Paper

Susceptibility genes in asthma and allergy

Current Allergy and Asthma Reports
C Ober

Abstract

Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at least 20 independent loci influence susceptibility to asthma, atopy, or associated phenotypes and indicates that the genetics of these phenotypes are truly complex. Ongoing studies are aimed at identifying the specific gene or genes in these regions that confer susceptibility to asthma or atopy.

References

Apr 1, 1992·Nature Genetics·F S Collins
Apr 1, 1992·Journal of Medical Genetics·R P YoungJ M Hopkin
Apr 1, 1995·Nature Genetics·F S Collins
Oct 9, 1993·Lancet·J M ColléeJ Gerritsen
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·I J DoullN E Morton
Sep 19, 1996·Nature·S E DanielsW O Cookson
Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M F Moffatt, W O Cookson
Dec 10, 1998·Nucleic Acids Research·T Immervoll, M Wjst
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·F D MartinezR P Erickson
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·L J PalmerP N LeSöuef
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·K C BarnesT H Beaty
Dec 2, 1999·Nature Genetics·A F WrightM Pirastu
Feb 1, 2000·Immunology Today·I ShirakawaJ M Hopkin
Oct 12, 2000·American Journal of Human Genetics·J XuD A Meyers
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M H DizierF Demenais
Mar 20, 2001·Genetic Epidemiology·R A MathiasUNKNOWN CSGA (Collaborative Study of the Genetics of Asthma)

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Citations

Jul 10, 2002·Trends in Immunology·Stefan MartinJan C Simon
Dec 13, 2005·Journal of Occupational and Environmental Medicine·Robert J McCunney
Oct 14, 2005·Journal of the American Veterinary Medical Association·George E MooreLawrence T Glickman
Mar 5, 2004·Expert Opinion on Investigational Drugs·Hans Michael Haitchi, Stephen T Holgate
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·John W HollowayStephen T Holgate
Nov 29, 2005·The Medical Clinics of North America·Alexander N Greiner
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham Devereux
Aug 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R-F ChenK D Yang
Sep 14, 2011·The Mount Sinai Journal of Medicine, New York·Tania MucciJody Tversky
Aug 21, 2015·Journal of Translational Medicine·Yichun ZhuXiangdong Wang
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard A WalgrenHoward L McLeod
Sep 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alison K BauerSteven R Kleeberger

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