Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype

Gastroenterology
Anna AbulíGastrointestinal Oncology Group of the Spanish Gastroenterological Association

Abstract

Ten common low-penetrant genetic variants have been consistently associated with colorectal cancer (CRC) risk; little is known about the correlation between these variants and CRC phenotype. Characterization of such a correlation would improve CRC management and prevention programs. We assessed the association between these genetic variants and CRC phenotype in patients and modeled pairwise combinations to detect epistasis. The validation population corresponded to a prospective, multicenter, population-based cohort (EPICOLON I) of 1096 patients with newly diagnosed CRC. The replication set was an independent, prospective, multicenter Spanish cohort (EPICOLON II) of 895 patients with newly diagnosed CRC. For individual single nucleotide polymorphism (SNP) association analyses, a multivariate method using logistic regression was applied in EPICOLON I and subsequently prospectively validated in EPICOLON II. Interactions between SNPs were assessed using the likelihood ratio test. Validated results confirmed that the C allele on 8q23.3 (rs16892766) was significantly associated with advanced-stage tumors (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.15-1.90; P value = 4.9 x 10(-3)). The G allele on 8q24.21 (rs6983267) was ...Continue Reading

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Citations

Nov 13, 2012·PloS One·Miranda V McEwanJulia A Horsfield
Jan 20, 2011·World Journal of Gastroenterology : WJG·Jian-Qiang JinLing-Yun Xia
Jan 15, 2014·World Journal of Gastroenterology : WJG·Sébastien KüryStéphane Bezieau
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Jan 26, 2013·Gastroenterology·Antoni Castells, Francis M Giardiello
Jan 29, 2013·Gastroenterology·María Rodríguez-SolerRodrigo Jover
May 1, 2012·Best Practice & Research. Clinical Gastroenterology·Angel FerrándezAntoni Castells
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Jan 7, 2014·Annals of Surgical Oncology·Keishi SugimachiKoshi Mimori
Jul 27, 2021·Pharmacogenomics and Personalized Medicine·Hongying ZhaoZixue Xuan

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