Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish population

Allergy
L M BuM Nordenskjold

Abstract

Atopic dermatitis (AD) is a hereditary, pruritic, chronic, relapsing, inflammatory skin disease resulting from multiplex interactions between genes and environmental factors. We have previously found several loci showing suggestive linkage on chromosomes 3q14, 13q14, 15q14-15 and 17q21, and weaker linkage to chromosomes 1p32, 4q24-26 and 21q21 in 109 Swedish families. In order to confirm the linkage to chromosome 21, we carried out a replication linkage analysis with additional microsatellite markers on chromosome 21 in another set of 295 families. In the extended material, the Z-score was 2.40 (P < 7.4 x 10(-4)) in the region 21q21 for a semi-quantitative variable measurement; the severity of AD. When combining the two data sets into 404 families and stratifying according to asthma status, suggestive linkage was found only in the group of AD patients who also had asthma (Z-score 2.45, P < 7.4 x 10(-4) and 2.69, P < 7.4 x 10(-4)) in two different regions. Our results suggest that 21q21 could contain a susceptibility gene modulating the severity of AD especially in combination with asthma.

References

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Citations

Nov 26, 2008·World Journal of Surgery·Min LiChangyi Chen
Sep 6, 2007·Journal of Structural and Functional Genomics·George N PhillipsSimon N Twigger
Apr 28, 2007·Science·Antony RodriguezAllan Bradley
Jun 15, 2007·Protein Science : a Publication of the Protein Society·Norberto B de la CruzBrian F Volkman
Feb 16, 2008·The Journal of Biological Chemistry·Sudheer Kumar GaraRaimund Wagener

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.