Susceptibility of 100 strains of Stenotrophomonas maltophilia to three beta-lactams and five beta-lactam-beta-lactamase inhibitor combinations

The Journal of Antimicrobial Chemotherapy
M Lecso-Bornet, E Bergogne-Bérézin

Abstract

One hundred clinical strains of Stenotrophomonas maltophilia were investigated for their susceptibility to ticarcillin, piperacillin, ceftazidime and five combinations with beta-lactamase inhibitors (clavulanic acid, tazocillin or sulbactam) at three concentrations; 26% of the strains were susceptible to ticarcillin, 23% to ceftazidime and 12% to piperacillin. Eighty-two percent of the strains were susceptible to ticarcillin/clavulanic acid. In most cases, no synergy was observed with tazobactam or sulbactam. For eight ticarcillin-susceptible strains, antagonism was observed between ticarcillin and clavulanic acid.

Citations

Mar 6, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A C Nicodemo, J I Garcia Paez
Oct 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Paola Sandra MercuriMoreno Galleni
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·S ValdezateR Cantón
Feb 7, 2018·Indian Journal of Medical Microbiology·Lipika SinghalVikas Gautam
Jul 21, 2020·Pharmacotherapy·Hannah K SpencerSamuel L Aitken
Jan 31, 2002·The Annals of Pharmacotherapy·Nathan P DownhourDavid E Nix

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