Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice

Experimental Parasitology
Michele Costa-SilvaArnaldo Maldonado-Júnior

Abstract

The therapeutic effects of praziquantel (PZQ) against a Schistosoma mansoni isolate derived from Nectomys squamipes (isolate R) and a susceptible isolate (BH) were analyzed in Swiss mice by fecal egg counting, adult worm reduction and oogram pattern. Infected mice were orally administrated with 62.5mg/kg (group 1), 125mg/kg (group 2), 250mg/kg (group 3) and 500mg/kg (group 4), each dose divided over 3 days (49, 50 and 51 days after infection). The data were analyzed using one-way analysis of variance (ANOVA). In regard to isolate R, no fecal eggs were observed with 250 mg/Kg and 500 mg/kg (p<0.05), whereas BH excretion reached zero with all doses. Mean worm burden reduction was significantly (p<0.05) higher at the two highest concentrations, regardless of isolate. At 62.5mg/kg, the percentage of immature eggs varied from 17% (isolate R) to 38% (isolate BH). At 125 mg/kg, the percentage of immature eggs varied from 20% (isolate R) to 16% (isolate BH). At 250 mg/kg, immature eggs dropped significantly to 1% (isolate R) and 4% (isolate BH). At 500 mg/kg, no immature eggs were found in isolate R, whereas in BH was 8%. No dosage significantly (p>0.05) affected the percentage of mature eggs, regardless of isolate. There was a large i...Continue Reading

References

Jul 21, 1977·Zeitschrift Für Parasitenkunde·R Gönnert, P Andrews
Jan 1, 1978·Transactions of the Royal Society of Tropical Medicine and Hygiene·R T MelloJ Pellegrino
Feb 1, 1975·International Journal for Parasitology·P T LoVerde
Nov 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·A L RabelloJ R Lambertucci
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·R Rodrigues e SilvaL Rey
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·V A De SouzaL Rey
Jan 1, 1991·Memórias do Instituto Oswaldo Cruz·N AraújoN Katz
Jul 1, 1991·Revista Do Instituto De Medicina Tropical De São Paulo·J R Machado e SilvaL Rey
Jun 1, 1986·Experimental Parasitology·A A SabahM J Doenhoff
Feb 1, 1988·Experimental Parasitology·M K Shaw, D A Erasmus
Jul 1, 1981·Memórias do Instituto Oswaldo Cruz·W L Paraense, L R Corrêa
Jan 1, 1993·Memórias do Instituto Oswaldo Cruz·K M DrescherG C Coles
May 1, 1997·Experimental Parasitology·P G FallonM J Doenhoff
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·S XiaoM Tanner
Sep 21, 2000·Acta Tropica·L ChitsuloL Savioli
Jun 14, 2002·International Journal for Parasitology·N B RodriguesA J Romanha
Mar 28, 2003·Brazilian Journal of Biology = Revista Brasleira De Biologia·C R BonvicinoL S Maroja
Jul 1, 1960·Transactions of the Royal Society of Tropical Medicine and Hygiene·G S NELSON
Jun 26, 2004·International Journal for Parasitology·Donato CioliMichael J Doenhoff
Sep 19, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Liliani Salum Alves MoreiraDavid Lee Nelson
May 17, 2007·Brazilian Journal of Biology = Revista Brasleira De Biologia·P S D'AndreaR Cerqueira
Nov 16, 1962·Science·F S BarbosaF Arruda
Aug 30, 2008·Acta Tropica·Celina Maria ModenaPaulo Marcos Zech Coelho
Sep 18, 2008·Memórias do Instituto Oswaldo Cruz·Neusa AraújoNaftale Katz
Sep 25, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Elaine Machado MartinezJosé Roberto Machado-Silva
Nov 4, 2008·Current Opinion in Infectious Diseases·Michael J DoenhoffJürg Utzinger
Aug 19, 2009·PLoS Neglected Tropical Diseases·Sandra D MelmanEric S Loker
Jul 6, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nicolas BechAndré Théron
Dec 2, 2010·The American Journal of Tropical Medicine and Hygiene·Poppy H L LambertonJoanne P Webster
Jan 15, 2011·Vector Borne and Zoonotic Diseases·Claire J StandleyJ Russell Stothard
Mar 23, 2011·PLoS Neglected Tropical Diseases·Ana K SarvelNaftale Katz
May 3, 2011·PloS One·Martha Charlotte HoltfreterEmil Christian Reisinger

❮ Previous
Next ❯

Citations

Dec 25, 2013·PLoS Neglected Tropical Diseases·Regina CoeliGuilherme Oliveira
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Anekécia Lauro da SilvaMaria do Carmo Alves de Lima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.