Susceptibility of Aspergillus strains from culture collections to amphotericin B and itraconazole

The Journal of Antimicrobial Chemotherapy
P M Rath

Abstract

Susceptibility testing of 27 Aspergillus reference strains belonging to five species was performed using the microdilution broth method with yeast nitrogen broth and RPMI-1640. Similar results were found using the two media. The strains of Aspergillus fumigatus (n = 8) and Aspergillus niger (n = 4) had MICs of amphotericin B in the range 0.125-0.5 mg/L. In contrast, nine out of 13 strains of Aspergillus flavus and Aspergillus nidulans had MICs in the range 2-16 mg/L. All strains had MICs of itraconazole in the range 0.03-0.5 mg/L. It is concluded that both media can be used for testing. Susceptibility testing to amphotericin B is recommended in clinical settings.

Citations

Mar 11, 2000·British Journal of Haematology·P C HuijgensA C Van Loenen
Dec 20, 2000·The Journal of Infection·C B MooreD W Denning
Oct 21, 2016·Nano Letters·Andreas VetterWolfram H P Pernice
Jan 31, 2002·The Annals of Pharmacotherapy·Fawziah MarraRobert D Levy
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·David W. WarnockRen-Kai Li
Apr 4, 2000·Journal of Clinical Microbiology·T HenryS H Hinrichs

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