Susceptibility of Biomphalaria glabrata to infection with Echinostoma paraensei: correlation with the effect of parasite secretory-excretory products on host hemocyte spreading

Journal of Invertebrate Pathology
G DeGaffé, E S Loker

Abstract

Susceptibility of the snail Biomphalaria glabrata to infection with the digenetic trematode Echinostoma paraensei was correlated with the ability of secretory-excretory products (SEP) derived from sporocysts of this parasite to interfere with the spreading behavior of host hemocytes in an in vitro assay. In 15 separate experiments, the prevalence of infection achieved by miracidia was positively correlated (C.C. = 0.779, P < 0.001) with the ability of in vitro-transformed sporocysts derived from the same batches of miracidia to produce SEP that inhibited host hemocyte spreading. Under assay conditions reflecting differences in hemolymph volumes between juvenile snails (susceptible to infection) and adult snails (relatively refractory to infection), SEP had a significantly greater effect on hemocytes from juvenile snails. No significant differences in response to SEP were noted when equivalent numbers of adult and juvenile hemocytes were used in the assay. Snails of the M line strain of B. glabrata are significantly more susceptible to infection with E. paraensei than 13-16-R1 strain snails. Exposure to SEP significantly increased the number of unspread hemocytes for both strains. However, significantly more 13-16-R1 than M line...Continue Reading

Citations

Jun 2, 2005·Frontiers in Zoology·Erik E Osnas, Curtis M Lively
Apr 6, 2012·PLoS Neglected Tropical Diseases·Patrick C HaningtonEric S Loker
Sep 13, 2005·Journal of Helminthology·A Théron, C Coustau
Jul 30, 2020·The Journal of Parasitology·Jonathan H SchultzCoen M Adema
Jul 4, 2007·Molecular and Biochemical Parasitology·François GuillouBenjamin E F Gourbal

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