Susceptibility of brain and skin to bacterial challenge

Journal of Neurosurgery
M MendesG Rodeheaver

Abstract

The brain is a uniquely protected organ. Once the protective barriers are overcome, the brain is susceptible to bacterial infection. Using a reproducible rat model, the susceptibility of brain tissue to challenge by S. aureus or E. coli was quantitatively compared to that of skin. Brain was significantly more susceptible to the presence of bacteria than was the skin of the scalp. The development of infection in skin required at least 10(5) organisms, while brain infection could be produced with as few as 100 organisms.

References

Nov 1, 1978·Neurosurgery·E A Neuwelt, W K Clark
Nov 1, 1979·Journal of Neurosurgery·H R WinnG Rodeheaver

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Citations

Sep 1, 1992·Journal of Neuroscience Methods·J M NazzaroE A Neuwelt
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·W M ScheldG Rodeheaver
Oct 1, 1985·Annals of Emergency Medicine·R F Edlich
Jun 19, 2018·Expert Review of Anti-infective Therapy·Jacob BodilsenDiederik Van De Beek
Feb 1, 1993·Neurochemical Research·Z Y Xue, R M Grossfeld
Dec 6, 2001·Arquivos de neuro-psiquiatria·V P Dantas FilhoR G Terzi
Aug 27, 2019·Revue neurologique·M CantieraR Sonneville
Aug 1, 1983·Infection and Immunity·G T CostelloG T Rodeheaver

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Methods Mentioned

BETA
biopsy
biopsies

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