PMID: 9661012Jul 14, 1998Paper

Susceptibility of Chlamydia trachomatis to chlorhexidine gluconate gel

Antimicrobial Agents and Chemotherapy
M F LampeW E Stamm

Abstract

To identify topical antimicrobial preparations which may be effective in preventing the transmission of sexually transmitted diseases, we examined the activity of chlorhexidine gluconate (CHG) against Chlamydia trachomatis. Chlamydial elementary bodies were incubated with dilutions of CHG gel for various times from 0 to 120 min. An aliquot of each dilution was further diluted and was inoculated onto McCoy cell monolayers in individual wells in a 96-well microtiter plate. The cultures were incubated for 48 h, and the chlamydial inclusions were stained and counted. CHG gel diluted fourfold (0.0625% CHG) killed C. trachomatis serovar D, and CHG gel diluted eightfold (0.0313% CHG) killed serovar F immediately upon exposure. CHG gel diluted 16-fold (0.0156% CHG) killed serovar D, and CHG gel diluted 32-fold (0.0078% CHG) killed serovar F after 120 min of exposure. Alteration of the pH over the range of from 4 to 8 did not significantly affect its activity. The addition of 10% whole human blood decreased the CHG gel activity at 0 min but had no significant effect after 120 min of exposure. We conclude that CHG gel may be effective topically against C. trachomatis at concentrations that can be used and under conditions that are found ...Continue Reading

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Citations

Sep 10, 2002·Sexually Transmitted Diseases·Bushra YasinRobert I Lehrer
Nov 20, 2002·Sexually Transmitted Diseases·Sharon L AchillesRichard A Cone
May 27, 2005·Antimicrobial Agents and Chemotherapy·Tsutomu YamazakiYukihiko Hara
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·M F LampeW E Stamm
Apr 3, 2004·Letters in Applied Microbiology·T YamazakiT Hayashi
May 27, 2005·Antimicrobial Agents and Chemotherapy·Hiroaki YamanoToshio Kishimoto
May 21, 1998·Antimicrobial Agents and Chemotherapy·M F LampeW E Stamm

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