Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631

Virology
L SironiP Mariani

Abstract

Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.

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Citations

Jun 3, 2011·Journal of Virology·Benjamin SchusserSonja Härtle
Jun 23, 2010·Genetics and Molecular Research : GMR·L SironiP Mariani
Mar 4, 2014·The Journal of General Virology·Anna V CauldwellWendy S Barclay
Jun 12, 2013·Developmental and Comparative Immunology·Kate E GoossensAndrew G D Bean
Dec 4, 2012·Biochemical and Biophysical Research Communications·Keisuke SasakiTomomasa Watanabe
Mar 18, 2015·PloS One·Wenke RuanYanhua Wu
Sep 4, 2016·Veterinary Immunology and Immunopathology·Christina PolaskyAngela Berndt
Mar 9, 2017·International Reviews of Immunology·Anamika MishraAshwin Ashok Raut
Nov 7, 2017·Animal : an International Journal of Animal Bioscience·W Drobik-CzwarnoJ C M Dekkers
Jun 18, 2011·Journal of Virology·Petra ZimmermannGeorg Kochs
Jan 17, 2019·Journal, Genetic Engineering & Biotechnology·Mohamed S HassananeNagwa A Hassan
Feb 16, 2017·Frontiers in Immunology·Diwakar SanthakumarMuhammad Munir
Oct 18, 2018·Viruses·Fong Yang LooiKirsty R Short
Feb 6, 2021·The Journal of General Virology·Anabel L ClementsMunir Iqbal

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