PMID: 9632620Jun 25, 1998Paper

Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor

Infection and Immunity
S M FleiszigK E Mostov

Abstract

Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K MatsumotoT Nakamura
Jan 1, 1985·The Journal of Membrane Biology·L Gonzalez-MariscalM Cereijido
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·R J MasonJ M Shannon
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KawaidaT Nakamura
Dec 1, 1996·Molecular Microbiology·T L YahrD W Frank
Feb 7, 1997·The Journal of Biological Chemistry·D F BalkovetzK E Mostov

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Citations

Dec 14, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Suzanne M J Fleiszig
Dec 1, 2010·Infection and Immunity·Danielle K AugustinSuzanne M J Fleiszig
Sep 7, 2001·Annual Review of Microbiology·B I KazmierczakJ N Engel
Apr 12, 2001·Cellular Microbiology·T K GeiserJ N Engel
Nov 5, 2003·Molecular Biology of the Cell·Barbara I KazmierczakJoanne N Engel
Oct 9, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Suzanne M J Fleiszig, David J Evans
Jun 24, 2003·Infection and Immunity·Suzanne M J FleiszigDavid J Evans
Dec 11, 2003·American Journal of Physiology. Renal Physiology·Daniel F BalkovetzJoshua H Lipschutz
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z C ChroneosJ A Whitsett
Feb 24, 2001·Cellular Microbiology·B I KazmierczakJ N Engel
Jul 17, 1999·The American Journal of Physiology·A LeeT Machen
Nov 23, 2019·Progress in Retinal and Eye Research·Suzanne M J FleiszigDavid J Evans
Sep 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephanie J WanSuzanne M J Fleiszig

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