Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.

Antimicrobial Agents and Chemotherapy
R M LevinM G Dunphy

Abstract

Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.

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Citations

Apr 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KanellakopoulouA Avlamis
Feb 17, 1999·Diagnostic Microbiology and Infectious Disease·T BalkoD J Hoban
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Aug 1, 1983·Antimicrobial Agents and Chemotherapy·C LaferriereD F Welch
Jun 7, 2019·The Journal of Antimicrobial Chemotherapy·Justin R Lenhard, Zackery P Bulman
Jun 1, 1984·Drug Intelligence & Clinical Pharmacy·S R EricksonM J Rybak

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