PMID: 8971035Dec 1, 1996Paper

Susceptibility of human bone marrow cells and hematopoietic cell lines to coxsackievirus B3 infection

Journal of Virology
Tytti VuorinenTimo Hyypiä

Abstract

Viremia is commonly observed in association with enterovirus infections, and during this phase viruses can be transmitted to secondary target organs in the body. It is not known, however, whether blood cells play a role in the pathogenesis of enterovirus infection supporting virus replication. Our earlier work (T. Vuorinen, R. Vainionpää, H. Kettinen, and T. Hyypiä, Blood 84:823-829, 1994) demonstrated that coxsackievirus B3 is able to replicate in representatives of B- and T-cell lines but not in a monocytic cell line or peripheral blood mononuclear cells, indicating that virus replication may depend on the differentiation and maturation stages of the cells. Therefore, we have broaden our studies and analyzed the susceptibility of granulocyte-macrophage CFU and hematopoietic cell lines with various differentiation and maturation stages to coxsackievirus B3 infection. Virus replication was detected in B- and T-cell lines with no direct correlation to the maturation stage. Granulocyte-macrophage CFU were also able to support virus multiplication.

References

Dec 1, 1989·The Journal of General Virology·T HyypiäM Maaronen
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Citations

Jul 15, 2003·Journal of Virology·José C SegoviaJuan A Bueren
May 24, 2007·Apoptosis : an International Journal on Programmed Cell Death·Nadine JaraschAndreas Henke
Dec 24, 1997·Clinical and Experimental Pharmacology & Physiology·C M CarthyB M McManus
Aug 18, 2010·Viral Immunology·Nadine Jarasch-AlthofAndreas Henke
Jun 21, 2017·The Journal of General Virology·Maria AnastasinaSarah Butcher
Jan 22, 2011·Virology·Ross E RhoadesRalph Feuer

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