PMID: 7546902Jul 1, 1995Paper

Susceptibility of human monocytes to HIV type 1 infection in vitro is not dependent on their level of CD4 expression

AIDS Research and Human Retroviruses
S SonzaS M Crowe

Abstract

Monocytes from HIV-seronegative persons were analyzed for CD4 expression and susceptibility to infection with HIV-1 on the day of isolation and following 1, 2, and 7 days in culture. Although surface CD4 was readily detected on freshly isolated monocytes, these cells were relatively resistant to infection. After 1 to 2 days in culture, when surface expression of CD4 had decreased over 90% to near background levels, cells became susceptible to infection with HIV-1. CD4 expression on monocytes cultured for 7 days was more than four times higher than that on freshly isolated cells, and the cultured cells were fully permissive to infection. These observations suggest that the differing susceptibility of monocytes and monocyte-derived macrophages to infection with HIV-1 is not simply proportional to the level of surface CD4 expression.

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Citations

Jan 13, 2012·Current HIV/AIDS Reports·Kathryn Twigg ArrildtRonald Swanstrom
Jul 10, 1998·Veterinary Immunology and Immunopathology·K KedzierskaS M Crowe
Jul 1, 1996·AIDS Research and Human Retroviruses·S R LewinS M Crowe
Dec 1, 1995·Australian and New Zealand Journal of Medicine·S M Crowe
Apr 9, 2010·Retrovirology·Anna Bergamaschi, Gianfranco Pancino
Mar 17, 2009·Journal of Leukocyte Biology·Clare L V WesthorpeSuzanne M Crowe
Jan 8, 2003·Reviews in Medical Virology·Katherine KedzierskaAnthony L Cunningham
Mar 23, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P A VelillaM T Rugeles
Sep 23, 2014·Journal of Neurovirology·Sarah B JosephRonald Swanstrom
Dec 6, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine KedzierskaSuzanne M Crowe
Sep 10, 2003·Journal of Leukocyte Biology·Maureen M GoodenowJohn W Sleasman
Jan 10, 2002·The Journal of Biological Chemistry·Jiangfeng SunMichel J Tremblay
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip J EllerySuzanne M Crowe
Dec 23, 2017·Current HIV Research·Olivia D Council, Sarah B Joseph
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-François GiguèreMichel J Tremblay
Apr 28, 1999·Trends in Microbiology·S UgoliniQ J Sattentau

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