Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions.

Emerging Infectious Diseases
Marcelo A BarriaMark W Head

Abstract

Chronic wasting disease (CWD) is a contagious and fatal neurodegenerative disease and a serious animal health issue for deer and elk in North America. The identification of the first cases of CWD among free-ranging reindeer and moose in Europe brings back into focus the unresolved issue of whether CWD can be zoonotic like bovine spongiform encephalopathy. We used a cell-free seeded protein misfolding assay to determine whether CWD prions from elk, white-tailed deer, and reindeer in North America can convert the human prion protein to the disease-associated form. We found that prions can convert, but the efficiency of conversion is affected by polymorphic variation in the cervid and human prion protein genes. In view of the similarity of reindeer, elk, and white-tailed deer in North America to reindeer, red deer, and roe deer, respectively, in Europe, a more comprehensive and thorough assessment of the zoonotic potential of CWD might be warranted.

References

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Citations

Nov 22, 2019·Biological Reviews of the Cambridge Philosophical Society·Luis E EscobarClaudio Soto
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Marion M Simmons
Oct 29, 2020·Transboundary and Emerging Diseases·Hayden D HedmanNohra E Mateus-Pinilla
Feb 6, 2021·Biomolecules·Diane L Ritchie, Marcelo A Barria
Dec 23, 2020·Viruses·Satish K NemaniValerie L Sim
Feb 4, 2021·Voprosy virusologii·S L Kal'novT V Grebennikova
Dec 7, 2018·The Medical Journal of Australia·Ron Elisha
May 1, 2021·Viruses·Mark P Figgie, Brian S Appleby
Aug 20, 2021·Scientific Reports·Manci LiPeter A Larsen
Sep 8, 2021·Veterinary Research·Alicia OteroDebbie McKenzie
Sep 28, 2021·Acta Neuropathologica Communications·Zerui WangWen-Quan Zou

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Methods Mentioned

BETA
transgenic
PCR
electrophoresis

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