Susceptibility of Mexican brucella isolates to moxifloxacin, ciprofloxacin and other antimicrobials used in the treatment of human brucellosis

Scandinavian Journal of Infectious Diseases
Ahidé López-MerinoOscar Cardeñosa

Abstract

Brucellosis is a disease of domestic and wild animals that is transmitted to humans and exists worldwide. We assessed the in vitro activity of moxifloxacin, ciprofloxacin, tetracycline, doxicycline, rifampin, streptomycin and trimethoprim-sulfamethoxazole (TMP/SMX) against 97 Brucella strains isolated from clinical samples, animals and dairy products in Mexico. Fluoroquinolones showed an antibacterial activity similar to that of tetracyclines (MIC(90) 0.5). Other drugs commonly used against brucellosis were less active, such as rifampin (MIC(90) 2.0 microg/ml) and streptomycin (MIC(90) 4.0 microg/ml). TMP/SMX showed the poorest activity (MIC(90) 8.0 microg/ml). Fluoroquinolones, either first-generation or the newer 8-methoxi derivatives, might be useful in the therapy of brucellosis, which remains to be assessed in clinical trials.

References

Dec 1, 1978·The Journal of Infectious Diseases·C Ortiz-NeuH C Neu
Jan 1, 1989·Archives of Orthopaedic and Trauma Surgery·J Bruns, R Maas
Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E M Santos, F L Sapico

❮ Previous
Next ❯

Citations

Jun 3, 2005·The New England Journal of Medicine·Georgios PappasEpameinondas Tsianos
Jan 5, 2011·Antimicrobial Agents and Chemotherapy·Ryan C MavesEric R Hall
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Matthew E Falagas, Ioannis A Bliziotis
Aug 30, 2012·Annals of Clinical Microbiology and Antimicrobials·Mohamed Abdel-MaksoudErica Dueger
Oct 4, 2006·Annals of Clinical Microbiology and Antimicrobials·Aun TurkmaniYiannis Tselentis
Apr 12, 2011·Tropical Animal Health and Production·Geoffrey T FosgateAbiodun Adewale Adesiyun
Aug 11, 2006·Journal of Clinical Periodontology·Argelia Almaguer-FloresLaurie-Ann Ximenez-Fyvie
Mar 9, 2006·Clinical Orthopaedics and Related Research·Sotirios Tsiodras, Matthew E Falagas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.