Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection

Parasitology Research
A M AttallahHany M Elsheikha

Abstract

The present study tested the hypothesis that prenatal exposure of neonate Outbred albino mice to Schistosoma mansoni antigens (Ags) or antibodies (Abs) modulates their immunity against postnatal responses to infection. Persistence of maternal S. mansoni Abs and/or Ags in mice born to S. mansoni-infected mothers (IF-IMs) and noninfected mothers (IF-NMs) for up to 8 weeks after delivery was investigated. A higher level of anti-S. mansoni IgG Ab was detected in sera of 1-week-old mice born to IF-IM compared to controls. Then, immunoglobulin (Ig)G gradually decreased to the eight week. No anti-S. mansoni IgM Ab was detected in sera of these offspring at any week after delivery. Schistosoma Ags were detected in liver and kidney tissues of mice born to infected mothers. However, Ags decreased markedly till the sixth week in the liver but increased significantly at the sixth week in the kidney. Eight-week-old mice born to infected and noninfected mothers were infected with 200 S. mansoni ceracriae. Their sera and livers were collected for testing IgG and granuloma formation 6 weeks postinfection. Worms were collected via portal perfusion and counted. Anti-S. mansoni IgG level, size and number of liver granuloma, and worm burden were s...Continue Reading

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Citations

Apr 8, 2010·Parasitology Research·Patrícia d'Emery Alves SantosElizabeth Malagueño
Mar 25, 2014·Experimental Parasitology·Patrícia d'Emery Alves SantosValdênia Maria Oliveira Souza
Jul 22, 2014·The Journal of Allergy and Clinical Immunology·Kathrin StraubingerClarissa U Prazeres da Costa
Feb 13, 2016·Memórias do Instituto Oswaldo Cruz·Patrícia d'Emery Alves SantosValdênia Maria Oliveira de Souza
Oct 30, 2018·Parasite Immunology·Benjamin G DewalsWilliam G Horsnell
Jan 9, 2019·Frontiers in Immunology·Matthew Lacorcia, Clarissa U Prazeres da Costa
Mar 7, 2020·Parasitology Research·Gabriela Calixto Ribeiro de HolandaJosé Luiz de Lima Filho
Feb 2, 2021·PLoS Pathogens·Diana Cortés-SelvaKeke C Fairfax
Mar 9, 2021·The Journal of Allergy and Clinical Immunology·Matthew LacorciaClarissa Prazeres da Costa

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