Susceptibility of newborn rats to 3-ethylphenol and 4-ethylphenol compared with that of young rats

Congenital Anomalies
Mika TakahashiMakoto Ema

Abstract

Newborn rat studies were conducted with oral administration of 3-ethylphenol (3EP) and 4-ethylphenol (4EP) on postnatal days (PND) 4-21 to allow comparison of no observed adverse effect level (NOAEL) and unequivocally toxic level (UETL) with those from 28-day studies of young rats starting at 5-6 weeks of age. In the newborn rat studies, slightly lowered body weight was observed after 3EP treatment, and deaths, hypoactivity, Straub tail, deep respiration and delayed righting reflex were clearly observed after 4EP treatment. In the young rat studies, salivation, staggering gait, changes in the liver including high values of liver weight and alanine aminotransferase or total cholesterol and the lesions in the forestomach were clearly observed after 3EP and 4EP treatments. NOAELs of 3EP and 4EP in the newborn rat studies appeared to be almost 3 times lower than those in the young rat studies. As a clear toxicity of 3EP was not observed in newborn rats, UETLs were not established for 3EP. Regarding 4EP, UETL of young rats was 4-5 times higher than that of newborn rats. In conclusion, newborn rats were 3-5 times more susceptible to 3EP and 4EP than young rats.

References

Mar 2, 2002·The Journal of Toxicological Sciences·M KoizumiR Hasegawa
Jan 22, 2003·The Journal of Toxicological Sciences·Mutsuko KoizumiRyuichi Hasegawa
Jun 25, 2003·The Journal of Toxicological Sciences·Mutsuko KoizumiRyuichi Hasegawa
Apr 20, 2004·Toxicology Letters·Naemi FukudaMakoto Ema
Nov 30, 2004·Congenital Anomalies·Mika TakahashiMakoto Ema
Apr 1, 2005·The Journal of Toxicological Sciences·Mutsuko Hirata-KoizumiRyuichi Hasegawa

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Citations

Dec 13, 2006·Regulatory Toxicology and Pharmacology : RTP·R HasegawaM Ema
Nov 6, 2007·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Sierra Rayne, Nigel J Eggers
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura

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