Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris

Archivum Immunologiae Et Therapiae Experimentalis
Janusz MarcinkiewiczMarta Targosz

Abstract

Taurine chloramine (TauCl) and taurine bromamine (TauBr) are the main haloamines produced by activated neutrophils. TauCl exerts both anti-inflammatory and microbicidal activities. Clinical studies showed that TauCl may be useful as an antimicrobial agent in the local treatment of infections. Much less is known about TauBr. Circumstantial evidence suggests that Propionibacterium acnes (PA) has a role in the inflammation of acne. Available topical therapies include antimicrobial agents which reduce total PA numbers and anti-inflammatory agents which suppress activity of the cells present in acne inflammatory lesions. In this study the bactericidal activities of TauBr and TauCl against PA and Staphylococcus epidermidis (SE), as a control strain, were investigated. Moreover, the influence of these haloamines on the generation of reactive oxygen species (ROS) by activated neutrophils was also tested. TauBr and TauCl were prepared by reaction of taurine with HOBr and HOCl, respectively. The reaction was monitored by UV absorption spectra. The bactericidal activities of TauBr and TauCl were determined by the pourplate method. The generation of ROS by neutrophils was determined by luminol chemiluminescence assay. In our experimental s...Continue Reading

Citations

Apr 29, 2006·American Journal of Respiratory Cell and Molecular Biology·Joshua G McCaskillStephen L Tilley
Sep 11, 2010·Journal of Biomedical Science·Janusz Marcinkiewicz
Jul 20, 2012·Amino Acids·Janusz Marcinkiewicz, Ewa Kontny
Jun 25, 2008·Seminars in Immunopathology·Balázs RadaErzsébet Ligeti
May 18, 2012·Dermatologic Therapy·Rana Majd MaysSirunya Silapunt
Aug 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lizelle FoxMinja Gerber
Jan 27, 2009·Bioorganic & Medicinal Chemistry Letters·Timothy P ShiauRakesh Jain
Mar 2, 2011·Expert Opinion on Pharmacotherapy·Thrasivoulos TzellosChristos C Zouboulis
Sep 23, 2020·Nutrients·Tawar QaradakhiAnthony Zulli
Jun 7, 2018·International Journal of Women's Dermatology·A U TanA S Paller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Janusz MarcinkiewiczW Maśliński
International Journal of Cosmetic Science
M Kanlayavattanakul, N Lourith
Expert Opinion on Pharmacotherapy
Thrasivoulos TzellosChristos C Zouboulis
© 2022 Meta ULC. All rights reserved