PMID: 9427165Jan 14, 1998Paper

Susceptibility of Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis to 10 Kampo formulations

The Journal of International Medical Research
S HigakiY Hasegawa

Abstract

We examined the in vitro sensitivities of three bacteria: Propionibacterium acnes, and Staphylococcus epidermidis, commonly detected in acne lesions, and Staphylococcus aureus, a common cause of skin infections, to 10 Kampo formulations (Chinese herbal medicines; combinations of powdered extracts of crude drugs). Both Staphylococcus species showed similar sensitivities to all 10 formulations, with minimum inhibitory concentrations (MICs) ranging from 25 to 400 mg/ml. P. acnes, however, was particularly sensitive to one formulation, keigai-rengyo-to (MIC, 0.78-25 mg/ml), prompting speculation that it might contain components with strong antibacterial activity to P. acnes. P. acnes showed similar sensitivities to all the other formulations (MIC 6.25-200 mg/ml). The ranges of MICs and the MIC50S (concentrations that inhibit 50% of isolates) were very similar to those previously recorded in 1990 for the two Staphylococcus species.

Citations

Aug 8, 2014·Phytotherapy Research : PTR·Whitney A FiskRaja K Sivamani
Jun 1, 2010·American Journal of Clinical Dermatology·Juliane ReuterChristoph M Schempp
Jul 31, 2018·Dermatology Research and Practice·Kotaro ItoShinichi Imafuku
Apr 22, 2011·Journal of Pharmacy Practice·Patty GhazviniH Stewart Goodman

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