PMID: 2503000Jun 1, 1989Paper

Susceptibility of Pseudomonas and Staphylococcus wound isolates to topical antimicrobial agents: a 10-year review and clinical evaluation

Burns : Journal of the International Society for Burn Injuries
P D ThomsonJ K Prasad

Abstract

A 10-year review of Ps. aeruginosa and Staph. aureus susceptibility to various topical agents is presented. Susceptibility testing was performed using the agar well diffusion (AWD) method. A reduction in microbial growth to numbers less than 10(5) per gram of tissue in the wound, measured by quantitative biopsy, was compared with predicted susceptibility test results. In this measurement of clinical efficacy, silver sulphadiazine and mafenide acetate compared most favourably with AWD results, 83 per cent and 82 per cent respectively. However, nitrofurazone only reduced bacterial counts to less than 10(5) per gram 42 per cent of the time when an inhibition zone was present. Hydrogen peroxide solution (1 per cent) was 100 per cent effective by the AWD test, but no relationship to clinical efficacy could be shown. Minimal inhibitory concentration (MIC) data for gentamicin sulphate was compared to AWD and showed a positive relationship of greater than 80 per cent for both organisms. The AWD test has been a useful aid in the decision-making process for the choice of topical agent by providing data which eliminates agents inappropriate for use.

References

Nov 1, 1975·American Journal of Surgery·T J Krizek, M C Robson
Apr 1, 1965·British Journal of Plastic Surgery·D WYNN-WILLIAMS, G MONBALLIU

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Citations

Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Alice N NeelyRichard J Kagan
Mar 20, 2008·The Journal of Trauma·Laurie C D'AvignonLeopoldo C Cancio
Sep 20, 2011·The Journal of Trauma·Laurie C D'AvignonUNKNOWN Prevention of Combat-Related Infections Guidelines Panel
Oct 1, 1994·Burns : Journal of the International Society for Burn Injuries·I A Holder, S T Boyce
Feb 1, 1990·Burns : Journal of the International Society for Burn Injuries·T E TaddonioJ K Prasad
Jun 15, 2010·Burns : Journal of the International Society for Burn Injuries·Jessie S GlasserClinton K Murray

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