Susceptibility of Select Agents to Predation by Predatory Bacteria

Microorganisms
Riccardo RussoNancy D Connell

Abstract

Select Agents are microorganisms and toxins considered to be exploitable as biological weapons. Although infections by many Select Agents can be treated by conventional antibiotics, the risk of an emerging or engineered drug resistant strain is of great concern. One group of microorganisms that is showing potential to control drug resistant Gram-negative bacteria are the predatory bacteria from the genera Bdellovibrio spp. and Micavibrio spp. In this study, we have examined the ability of Bdellovibrio bacteriovorus (B. bacteriovorus) strain 109J, HD100 and Micavibrio aeruginosavorus (M. aeruginosavorus) ARL-13 to prey on a variety of Select Agents. Our findings demonstrate that B. bacteriovorus and M. aeruginosavorus are able to prey efficiently on Yersinia pestis and Burkholderia mallei. Modest predation was also measured in co-cultures of B. bacteriovorus and Francisella tularensis. However, neither of the predators showed predation when Burkholderia pseudomallei and Brucella melitensis were used as prey.

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Citations

Feb 9, 2017·Canadian Journal of Microbiology·Damian McNeelySusan F Koval
Jan 19, 2020·Applied and Environmental Microbiology·Daniel YoudkesEdouard Jurkevitch

Related Concepts

Antibiotics
Brucella melitensis
Drug Resistance
Genetic Engineering
Gram-Negative Bacteria
Burkholderia mallei
Burkholderia pseudomallei
Toxin
Tularemia
Coculture Techniques

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