PMID: 6158811Feb 1, 1980

Susceptibility of Serratia marcescens to human serum: antagonism of serum bactericidal activity by IgG immunoglobulins of homologous rabbit anti-O sera

Zentralblatt Für Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten Und Parasitologie
W H Traub

Abstract

Absorption of fresh human serum with boiled or live homologous O-cells of Serratia marcescens in the cold (4 degrees C, 1 hour) completely abrogated killing activity against "delayed serum-sensitive" (DSS) strains of S. marcescens. In contrast, previously "promptly serum-sensitive" (PSS) strains of S. marcescens and the PSS control strain Escherichia coli C were killed kinetically in a slightly "delayed" fashion by antibody-depleted fresh human serum. Addition of 40 vol% of heat-inactivated homologous rabbit anti-O immune sera to 50 vol% of fresh human serum "blocked" bactericidal activity against DDS and PSS assay strains of S. marcescens. The "blocking" activity of rabbit anti-O immune sera was shown to reside in the crude gamma globulin fractions derived therefrom through precipitation with ammonium sulfate. Absorption of rabbit anti-O immune sera with boiled homologous O-cells failed to remove the "blocking" activity; the O-agglutination titers were reduced to nondetectable levels. However, dual absorptions of rabbit anti-O immune sera with killed cells of Staphylococcus aureus Cowan I (protein A) almost completely abolished "blocking" activity; the O-agglutinin titers of these immune sera were not reduced more than 4-fold....Continue Reading

Related Concepts

Antibodies, Bacterial
Blood Bactericidal Activity
Alkalescens-Dispar Group
Gamma globulin
Polyglobin
Immune Sera
Resistance, Natural
Immunosorbent Techniques
Serratia marcescens

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