Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Bryndís Ragnarsdóttir, Catharina Svanborg

Abstract

Our knowledge of the molecular mechanisms of urinary tract infection (UTI) pathogenesis has advanced greatly in recent years. In this review, we provide a general background of UTI pathogenesis, followed by an update on the mechanisms of UTI susceptibility, with a particular focus on genetic variation affecting innate immunity. The innate immune response of the host is critically important in the antibacterial defence mechanisms of the urinary tract, and bacterial clearance normally proceeds without sequelae. However, slight dysfunctions in these mechanisms may result in acute disease and tissue destruction. The symptoms of acute pyelonephritis are caused by the innate immune response, and inflammation in the urinary tract decreases renal tubular function and may give rise to renal scarring, especially in paediatric patients. In contrast, in children with asymptomatic bacteriuria (ABU), bacteria persist without causing symptoms or pathology. Pathogenic agents trigger a response determined by their virulence factors, mediating adherence to the urinary tract mucosa, signalling through Toll-like receptors (TLRs) and activating the defence mechanisms. In ABU strains, such virulence factors are mostly not expressed. However, the inf...Continue Reading

References

May 1, 1975·Acta paediatrica Scandinavica·U LindbergU Jodal
Apr 1, 1992·Infection and Immunity·S HedgesC Svanborg
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·H LombergC Svanborg
Mar 1, 1990·Scandinavian Journal of Immunology·S HedgesC Svanborg Edén
Aug 15, 1985·The New England Journal of Medicine·P O'HanleyG Schoolnik
Nov 1, 1986·Infection and Immunity·T K KorhonenH Holthöfer
Feb 1, 1989·American Journal of Epidemiology·K StenqvistC Svanborg-Edén
Jul 1, 1988·The Journal of Infectious Diseases·P de ManC S Edén
May 1, 1987·Infection and Immunity·C Svanborg-EdénL Ohman
May 1, 1986·The New England Journal of Medicine·G R NordenstamA Svanborg
Nov 1, 1985·Acta paediatrica Scandinavica·B WettergrenG Jonasson
Mar 7, 1981·Lancet·H LombergB Samuelsson
Aug 1, 1984·Journal of Bacteriology·T K KorhonenJ Finne
Mar 16, 1983·Biochemical and Biophysical Research Communications·J ParkkinenT K Korhonen
Mar 1, 1984·Infection·C Svanborg EdénS Michalec
Jan 1, 1980·The Journal of Clinical Investigation·M A Horwitz, S C Silverstein
Mar 1, 1995·Blood Reviews·G J Kontoghiorghes, E D Weinberg
Aug 1, 1993·The Journal of Clinical Investigation·W W AgaceC Svanborg
Mar 1, 1996·The Journal of Experimental Medicine·M HedlundC Svanborg
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·R MalaviyaS N Abraham
Sep 9, 2000·The Journal of Infectious Diseases·D ScholesW E Stamm

❮ Previous
Next ❯

Citations

Oct 23, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tryggve Nevéus
Oct 26, 2013·Nephron. Clinical Practice·Ebru AsiciogluCetin Ishak Ozener
Jun 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
Jun 19, 2014·Journal of the American Veterinary Medical Association·Stephanie Y WanKatrina R Viviano
Feb 8, 2013·European Journal of Pediatrics·Yakubov RenataAdi Klein-Kremer
May 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guo-Qiang ZhangYong Zhao
Feb 24, 2016·Frontiers in Cellular and Infection Microbiology·Deepak S IpeGlen C Ulett
Nov 11, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Fredrik Sundén, Björn Wullt
Feb 4, 2014·Infectious Disease Clinics of North America·Betsy Foxman
Feb 4, 2014·Infectious Disease Clinics of North America·Ann E Stapleton
Feb 8, 2014·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Katharine O'Dell
Mar 12, 2016·Journal of the American Society of Nephrology : JASN·Silvia GhirottoOlivier Devuyst
Oct 18, 2015·The Urologic Clinics of North America·Matthew Ferroni, Aisha Khalali Taylor
May 9, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·John M Rosen, David J Klumpp
Apr 11, 2015·Advanced Drug Delivery Reviews·María Elena Fátima Nader-Macías, María Silvina Juárez Tomás
Aug 6, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luciana RobinoRafael Vignoli
Jun 3, 2016·BioMed Research International·Panagiota KarananouEfimia Papadopoulou-Alataki
Dec 7, 2016·Nature Reviews. Urology·Carsten LeueGommert van Koeveringe
Oct 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julien CoussementOlivier Denis
Dec 4, 2012·Expert Review of Anti-infective Therapy·Maria Bitsori, Emmanouil Galanakis
Jun 24, 2016·American Journal of Physiology. Renal Physiology·Pradeep TyagiMichael Chancellor
Dec 30, 2014·Current Opinion in Infectious Diseases·Gabriela GodalyCatharina Svanborg
Sep 15, 2016·Expert Review of Anti-infective Therapy·Moritz FritzenwankerFlorian M Wagenlehner
Jan 3, 2018·Pediatrics in Review·Eric Balighian, Michael Burke
Dec 19, 2019·Frontiers in Immunology·Brian BecknellJohn David Spencer
Apr 17, 2020·Innate Immunity·Aslam H QureshiDavid S Hains
Jun 15, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christina ChingBrian Becknell
Oct 9, 2020·Physiological Reports·Jeffrey M PurkersonGeorge J Schwartz
Mar 31, 2019·The American Journal of Pathology·Jacob R TherkildsenHelle A Praetorius
Jul 18, 2015·Microbiology Spectrum·James P Nataro
Aug 24, 2021·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Luciano GarofaloDouglas Hanes
Jun 10, 2015·Pediatrics·Ron KerenAlejandro Hoberman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Nature Reviews. Urology
Greta R Nielubowicz, Harry L T Mobley
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jonas MarschallCDC Prevention Epicenters Program
© 2022 Meta ULC. All rights reserved