Susceptibility to ankylosing spondylitis but not disease outcome is influenced by the level of HLA-B27 expression, which shows moderate variability over time

Scandinavian Journal of Rheumatology
Alberto CauliA Mathieu

Abstract

Previous reports have highlighted the relevance of HLA-B27 expression in the pathogenesis of ankylosing spondylitis (AS). The aim of the current study was to estimate the level of HLA-B27 expression on the cell surface of ex vivo monocytes and lymphocytes by a quantitative method and to correlate this with AS disease susceptibility, disease clinical indexes, and the occurrence of acute anterior uveitis (AAU). We recruited 32 B27-positive patients with AS and 32 B27-positive healthy normal controls (NCs) for evaluation at different time points. The expression of HLA-B27 molecules was quantified by flow cytometry on ex vivo peripheral blood mononuclear cells (PBMCs). Patients were also evaluated by scores on the Bath AS disease activity (BASDAI), functional (BASFI), and metrology (BASMI) indexes. The expression of HLA-B27 molecules was significantly higher in patients with AS than in B27-matched controls in the case of both monocytes [219K (IQR 174K-308K) vs. 137K (IQR 96K-170K), p < 0.0001] and lymphocytes [82K (IQR 58K-118K) vs. 54K (IQR 44K-61K), p < 0.0001]; AS only vs. AS with AAU: p = 0.744 in monocytes and p = 0.701 in lymphocytes. Comparisons with metrology and functional indexes were also not significant (BASMI: r = 0.05...Continue Reading

References

Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew J TurnerRobert A Colbert
Sep 30, 2008·Scandinavian Journal of Rheumatology·Y-M ChungC-P Tsai
Jan 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul BownessSimon Kollnberger

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Citations

Sep 3, 2013·Molecular Immunology·Robert A ColbertGerlinde Layh-Schmitt
Jun 20, 2013·Clinical & Developmental Immunology·Taha RashidAlan Ebringer
Dec 22, 2016·International Journal of Molecular Sciences·Lianjun YangHai Lu
Nov 11, 2014·Drug Development Research·Alberto CauliAlessandro Mathieu
Dec 23, 2020·International Journal of Molecular Sciences·Valentina TedeschiMaria Teresa Fiorillo

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