PMID: 8585760Sep 1, 1995Paper

Susceptibility to herpes labialis following multiple experimental exposures to ultraviolet radiation

Antiviral Research
S L SpruanceM B McKeough

Abstract

We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/29 (72%) of lesions sampled. Three patients never developed a lesion, 13 developed lesions on one or two of the three occasions, and 4 patients had a lesion following all three sessions. Seven of 33 (21%) lesions were 'immediate' lesions (developed within 48 h) and the others developed 3-7 days after UVR exposure (delayed lesions). Development of lesions correlated with historical susceptibility to sun-induced herpes labialis, but not with age, sex, years with herpes labialis, frequency of herpes labialis from all causes, or concurrent serum levels of cortisol, dehydroepiandrosterone, estradiol, progesterone or alpha 1-antitrypsin. Among normally menstruating females, a significant association was identified between the development of herpes labialis and the luteal phase of the menstrual cycle (8 cases of herpes labialis/11 attempts, RR = 14, P = 0.005). The lack of correlation between episodes of natural herpes lab...Continue Reading

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Citations

Jan 18, 2008·The Journal of Infectious Diseases·Maurine R HobbsJohn D Kriesel
Oct 22, 2013·American Journal of Epidemiology·Christina LudemaKirk R Wilhelmus
Jul 29, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gonzalo HernándezJuan Carlos De Vicente
Oct 5, 2010·International Journal of Dermatology·Nicholas NguyenCraig G Burkhart
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Robert M SayreMingyi W Trimble
Oct 21, 2004·The Journal of the American Dental Association·Craig S MillerSergei A Avdiushko
Sep 6, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anthony CunninghamRichard Whitley
Sep 15, 2014·The Journal of Infection·Benson OgunjimiPhilippe Beutels
Oct 16, 2016·Journal of Neurovirology·Robert J DanaherCraig S Miller
Jun 25, 2020·Viruses·Anita F MeierMichael Seyffert
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sana ArshadNicole A Carnt

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