PMID: 3769975Aug 1, 1986Paper

Susceptibility to infections in children with selective IgA- and IgA-IgG subclass deficiency

European Journal of Pediatrics
A MorellE Rossi

Abstract

This study included 36 children with IgA-deficiency, increased susceptibility to infections and/or other disorders. Recurrent, usually bacterial infections were noticed in 23 out of 26 patients (88%) with complete and in 7 out of 10 patients (70%) with partial IgA-deficiency. All patients with severe infections had complete IgA-deficiency. Complete IgA-deficiency was also present in the six children who had autoimmune disorders associated with recurrent infections. In 22 out of the 36 patients studied the serum could be analysed for concomitant IgG subclass deficiencies: one patient had marked decrease of IgG2. In a second patient IgG4 was not detectable. Two patients had combined IgG2-IgG4-deficiency. In a girl with severe acute and chronic infections and relapsing idiopathic thrombocytopenic purpura, IgA-IgG2-IgG4-deficiency was found to be the prodromal stage of common variable immunodeficiency with panhypogammaglobulinaemia.

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Citations

Apr 1, 1988·European Journal of Pediatrics·U B SchaadA Morell
May 7, 2005·The Pediatric Infectious Disease Journal·Tamas FazekasAndreas Heitger
Sep 24, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Athina PapadopoulouKostas N Priftis
Apr 1, 1989·Clinical Immunology and Immunopathology·P AucouturierJ L Preud'Homme
Oct 1, 1988·The American Journal of Medicine·M J DiBenedettoR T Steigbigel
Sep 3, 2016·The Korean Journal of Internal Medicine·Woo-Jin KimHyeon-Wook Kang
Sep 12, 1998·Primary Care·R J Mamlock
Nov 1, 1991·The Journal of Allergy and Clinical Immunology·C RitterB M Stadler
Sep 28, 2010·Journal of Pediatric Gastroenterology and Nutrition·Anthony L GuerrerioMaria Oliva-Hemker
Jan 1, 1996·FEMS Immunology and Medical Microbiology·M B KalvenesG Haukenes
May 24, 2006·Pharmacotherapy·Tamar Koleba, Mary H H Ensom
Jul 8, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Volker Wahn, Horst von Bernuth
Aug 1, 1991·Acta paediatrica Scandinavica·P C De LaatG B Stoelinga

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